(S)-N'-cyano-N-(3-fluorophenyl)-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboximidamide

Base Information

• Chemical Name: (S)-N'-cyano-N-(3-fluorophenyl)-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboximidamide
• CAS No.: 1116571-03-9
• Molecular Formula: C₂₀H₂₁FN₈
• Molecular Weight: 392.439

Synonyms:(S)-N'-cyano-N-(3-fluorophenyl)-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboximidamide

Chemical Property of (S)-N'-cyano-N-(3-fluorophenyl)-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboximidamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N'-cyano-N-(3-fluorophenyl)-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboximidamide

There total 3 articles about (S)-N'-cyano-N-(3-fluorophenyl)-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

(S)-5-methyl-4-(3-methylpiperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine (1116570-96-7) + phenyl N'-cyano-N-(3-fluorophenyl)imidocarbamate (1001185-45-0) → (S)-N'-cyano-N-(3-fluorophenyl)-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboximidamide (1116571-03-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 85 ℃; for 4h;

Reference yield: 27.0%

(S)-5-methyl-4-(3-methylpiperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine (1116570-96-7) + phenyl N'-cyano-N-(3-fluorophenyl)imidocarbamate (1001185-45-0) → (S)-N'-cyano-N-(3-fluorophenyl)-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboximidamide (1116571-03-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 85 ℃; for 4h; Inert atmosphere; Sealed tube;

DOI:10.1021/jm901226j

Reference yield:

phenyl N'-cyano-N-(3-(trifluoromethyl)phenyl)carbamimidate, (250262-05-6) + (S)-5-methyl-4-(3-methylpiperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine (1116570-96-7) → (S)-N'-cyano-N-(3-fluorophenyl)-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboximidamide (1116571-03-9)

Guidance literature:

With triethylamine; In isopropyl alcohol; at 140 ℃; for 0.5h; Microwave irradiation;

upstream raw materials:

phenyl N'-cyano-N-(3-(trifluoromethyl)phenyl)carbamimidate,

(S)-5-methyl-4-(3-methylpiperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine

phenyl N'-cyano-N-(3-fluorophenyl)imidocarbamate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1116571-03-9 (S)-N'-cyano-N-(3-fluorophenyl)-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboximidamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send