1-<<3-<<2-amino-4-(trifluoromethyl)phenyl>amino>-1-methylpyrazol-4-yl>carbonyl>4-methylpiperazine

Base Information

Chemical Name:1-<<3-<<2-amino-4-(trifluoromethyl)phenyl>amino>-1-methylpyrazol-4-yl>carbonyl>4-methylpiperazine
CAS No.:122800-17-3
Molecular Formula:C₁₇H₂₁F₃N₆O
Molecular Weight:382.389
Hs Code.:

Synonyms:1-<<3-<<2-amino-4-(trifluoromethyl)phenyl>amino>-1-methylpyrazol-4-yl>carbonyl>4-methylpiperazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-<<3-<<2-amino-4-(trifluoromethyl)phenyl>amino>-1-methylpyrazol-4-yl>carbonyl>4-methylpiperazine

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Technology Process of 1-<<3-<<2-amino-4-(trifluoromethyl)phenyl>amino>-1-methylpyrazol-4-yl>carbonyl>4-methylpiperazine

There total 4 articles about 1-<<3-<<2-amino-4-(trifluoromethyl)phenyl>amino>-1-methylpyrazol-4-yl>carbonyl>4-methylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 109-01-3
1-methyl-piperazine

: 79291-60-4
ethyl 3-<<2-amino-4-(trifluoromethyl)phenyl>amino>-1-methylpyrazole-4-carboxylate

: 122800-17-3
1-<<3-<<2-amino-4-(trifluoromethyl)phenyl>amino>-1-methylpyrazol-4-yl>carbonyl>4-methylpiperazine

Guidance literature:: With titanium tetrachloride; In various solvent(s); at 65 ℃; for 0.5h;
DOI:10.1021/jm00132a012

Reference yield:

: 21230-43-3
3-amino-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester

: 122800-17-3
1-<<3-<<2-amino-4-(trifluoromethyl)phenyl>amino>-1-methylpyrazol-4-yl>carbonyl>4-methylpiperazine

Guidance literature:: Multi-step reaction with 3 steps

1: 1) n-BuLi / 1) THF, hexane, -15 deg C, 10 min, 2) THF, r.t., 1 h

2: 90 percent / H₂ / Pd/C(10percent) / ethyl acetate; ethanol / 3102.9 Torr

3: 65 percent / TiCl₄ / various solvent(s) / 0.5 h / 65 °C

With n-butyllithium; hydrogen; titanium tetrachloride; palladium on activated charcoal; In ethanol; ethyl acetate;
DOI:10.1021/jm00132a012

Reference yield:

: 367-86-2
1-fluoro-2-nitro-4-trifluoromethyl-benzene

: 122800-17-3
1-<<3-<<2-amino-4-(trifluoromethyl)phenyl>amino>-1-methylpyrazol-4-yl>carbonyl>4-methylpiperazine

Guidance literature:: Multi-step reaction with 3 steps

1: 1) n-BuLi / 1) THF, hexane, -15 deg C, 10 min, 2) THF, r.t., 1 h

2: 90 percent / H₂ / Pd/C(10percent) / ethyl acetate; ethanol / 3102.9 Torr

3: 65 percent / TiCl₄ / various solvent(s) / 0.5 h / 65 °C

With n-butyllithium; hydrogen; titanium tetrachloride; palladium on activated charcoal; In ethanol; ethyl acetate;
DOI:10.1021/jm00132a012