(2S,3R,4R)-4-tert-Butoxycarbonylamino-2,3-dihydroxy-5-trityloxy-pentanoic acid methyl ester

Base Information

Chemical Name:(2S,3R,4R)-4-tert-Butoxycarbonylamino-2,3-dihydroxy-5-trityloxy-pentanoic acid methyl ester
CAS No.:126199-66-4
Molecular Formula:C₃₀H₃₅NO₇
Molecular Weight:521.61
Hs Code.:

Synonyms:(2S,3R,4R)-4-tert-Butoxycarbonylamino-2,3-dihydroxy-5-trityloxy-pentanoic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R,4R)-4-tert-Butoxycarbonylamino-2,3-dihydroxy-5-trityloxy-pentanoic acid methyl ester

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Technology Process of (2S,3R,4R)-4-tert-Butoxycarbonylamino-2,3-dihydroxy-5-trityloxy-pentanoic acid methyl ester

There total 4 articles about (2S,3R,4R)-4-tert-Butoxycarbonylamino-2,3-dihydroxy-5-trityloxy-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 126179-16-6
(E)-(S)-4-tert-Butoxycarbonylamino-5-trityloxy-pent-2-enoic acid methyl ester

: 126199-66-4
(2S,3R,4R)-4-tert-Butoxycarbonylamino-2,3-dihydroxy-5-trityloxy-pentanoic acid methyl ester

Guidance literature:: With potassium osmate(VI); (DHQD)2PHAL; methanesulfonamide; potassium carbonate; potassium hexacyanoferrate(III); In water; tert-butyl alcohol; at 0 ℃; for 12h;
DOI:10.3987/COM-97-S11

Reference yield:

: 126179-16-6
(E)-(S)-4-tert-Butoxycarbonylamino-5-trityloxy-pent-2-enoic acid methyl ester

: (2R,3S,4R)-4-tert-Butoxycarbonylamino-2,3-dihydroxy-5-trityloxy-pentanoic acid methyl ester

: 126199-66-4
(2S,3R,4R)-4-tert-Butoxycarbonylamino-2,3-dihydroxy-5-trityloxy-pentanoic acid methyl ester

Guidance literature:: With potassium osmate(VI); hydroquinidine 9-phenanthryl ether; water; potassium carbonate; potassium hexacyanoferrate(III); In tert-butyl alcohol; at 0 ℃; for 24h; Title compound not separated from byproducts;
DOI:10.3987/COM-94-7016

Reference yield:

: 124665-88-9,124665-89-0,126179-15-5,126179-25-7
(S)-2-Oxo-3-phenylselanyl-5-trityloxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester

: 126199-66-4
(2S,3R,4R)-4-tert-Butoxycarbonylamino-2,3-dihydroxy-5-trityloxy-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / LiOH / tetrahydrofuran / 1 h / Ambient temperature

2: 89 percent / 30percent H₂O₂ / ethyl acetate / 0.25 h / Ambient temperature

3: potassium osmate dihydrate, hydroquinidine 9-phenanthryl ether, K₃Fe(CN)6, K₂CO₃, H₂O / 2-methyl-propan-2-ol / 24 h / 0 °C

With lithium hydroxide; potassium osmate(VI); hydroquinidine 9-phenanthryl ether; water; dihydrogen peroxide; potassium carbonate; potassium hexacyanoferrate(III); In tetrahydrofuran; ethyl acetate; tert-butyl alcohol;
DOI:10.3987/COM-94-7016