4-methyl-N-[(1S)-1-cyano-4,4,4-trifluoro-2-(2,2,2-trifluoroethyl)butyl]-(S)-benzenesulfinamide

Base Information

Chemical Name:4-methyl-N-[(1S)-1-cyano-4,4,4-trifluoro-2-(2,2,2-trifluoroethyl)butyl]-(S)-benzenesulfinamide
CAS No.:769169-80-4
Molecular Formula:C₁₄H₁₄F₆N₂OS
Molecular Weight:372.334
Hs Code.:

Synonyms:4-methyl-N-[(1S)-1-cyano-4,4,4-trifluoro-2-(2,2,2-trifluoroethyl)butyl]-(S)-benzenesulfinamide

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Chemical Property of 4-methyl-N-[(1S)-1-cyano-4,4,4-trifluoro-2-(2,2,2-trifluoroethyl)butyl]-(S)-benzenesulfinamide

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Technology Process of 4-methyl-N-[(1S)-1-cyano-4,4,4-trifluoro-2-(2,2,2-trifluoroethyl)butyl]-(S)-benzenesulfinamide

There total 10 articles about 4-methyl-N-[(1S)-1-cyano-4,4,4-trifluoro-2-(2,2,2-trifluoroethyl)butyl]-(S)-benzenesulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1029042-32-7
C₁₃H₁₃NOF₆S

: 5804-85-3
diethylaluminium cyanide

: 769169-80-4
4-methyl-N-[(1S)-1-cyano-4,4,4-trifluoro-2-(2,2,2-trifluoroethyl)butyl]-(S)-benzenesulfinamide

Guidance literature:: diethylaluminium cyanide; With isopropyl alcohol; In tetrahydrofuran; toluene; at 0 ℃; for 0.25h;

C₁₃H₁₃NOF₆S; In tetrahydrofuran; toluene; at -78 - 20 ℃; for 3h; Further stages.;
DOI:10.1016/j.bmcl.2007.02.041

Reference yield: 73.0%

: (S)-4-methyl-N-[(1Z)-4,4,4-trifluoro-2-(2,2,2-trifluoroethyl)butylidene]benzenesulfinamide

: 769169-80-4
4-methyl-N-[(1S)-1-cyano-4,4,4-trifluoro-2-(2,2,2-trifluoroethyl)butyl]-(S)-benzenesulfinamide

Guidance literature:: With diethylaluminium cyanide; In tetrahydrofuran; isopropyl alcohol; toluene; at -65 - 0 ℃; for 3.75h;
DOI:10.1021/op700259d

Reference yield:

: (E)-4,4,4-trifluoro-2-(2,2,2-trifluoro-ethyl)-but-2-enoic acid ethyl ester

: 769169-80-4
4-methyl-N-[(1S)-1-cyano-4,4,4-trifluoro-2-(2,2,2-trifluoroethyl)butyl]-(S)-benzenesulfinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 100 percent / H₂ / Pd/C / tetrahydrofuran / 760.05 Torr

2.1: 41 percent / LAH / diethyl ether

3.1: Dess-Martin periodinane / CH₂Cl₂ / 0 - 25 °C

4.1: Ti(OEt)4 / CH₂Cl₂ / 5 h / Heating

5.1: i-PrOH / toluene; tetrahydrofuran / 0.25 h / 0 °C

5.2: 81 percent / tetrahydrofuran; toluene / 3 h / -78 - 20 °C

With titanium(IV) tetraethanolate; lithium aluminium tetrahydride; hydrogen; Dess-Martin periodane; isopropyl alcohol; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;
DOI:10.1016/j.bmcl.2007.02.041