C₄₁H₄₄N₂O₆Si

Base Information

• Chemical Name: C₄₁H₄₄N₂O₆Si
• CAS No.: 1300589-67-6
• Molecular Formula: C₄₁H₄₄N₂O₆Si
• Molecular Weight: 688.896
• Mol file: 1300589-67-6.mol

Synonyms:C₄₁H₄₄N₂O₆Si

Chemical Property of C₄₁H₄₄N₂O₆Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₁H₄₄N₂O₆Si

There total 6 articles about C₄₁H₄₄N₂O₆Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3',5'-di-O-benzyl-4'-C-(tert-butyldiphenylsilyloxymethyl)-5-methyluridine (1300589-65-4) → C41H44N2O6Si (1300589-67-6)

Guidance literature:

With dmap; trifluoromethane sulfonyl chloride; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere; Cooling with ice;

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → C41H44N2O6Si (1300589-67-6)

Guidance literature:

Multi-step reaction with 5 steps

1: dmap; triethylamine / dichloromethane / 20 h / Inert atmosphere; Cooling; Reflux

2: sulfuric acid; acetic acid / 3.5 h

3: N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate / acetonitrile / 1 h / 20 °C / Inert atmosphere; Reflux

4: methylamine / water; tetrahydrofuran / 0.5 h / 20 °C

5: dmap; trifluoromethane sulfonyl chloride / dichloromethane / 1 h / 20 °C / Inert atmosphere; Cooling with ice

With dmap; N,O-bis-(trimethylsilyl)-acetamide; trifluoromethane sulfonyl chloride; trimethylsilyl trifluoromethanesulfonate; sulfuric acid; acetic acid; triethylamine; methylamine; In tetrahydrofuran; dichloromethane; water; acetonitrile;

Reference yield:

((3aR,5R,6S,6aR)-6-(benzyloxy)-5-((benzyloxy)methyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanol (153186-10-8) → C41H44N2O6Si (1300589-67-6)

Guidance literature:

Multi-step reaction with 5 steps

1: dmap; triethylamine / dichloromethane / 20 h / Inert atmosphere; Cooling; Reflux

2: sulfuric acid; acetic acid / 3.5 h

3: N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate / acetonitrile / 1 h / 20 °C / Inert atmosphere; Reflux

4: methylamine / water; tetrahydrofuran / 0.5 h / 20 °C

5: dmap; trifluoromethane sulfonyl chloride / dichloromethane / 1 h / 20 °C / Inert atmosphere; Cooling with ice

With dmap; N,O-bis-(trimethylsilyl)-acetamide; trifluoromethane sulfonyl chloride; trimethylsilyl trifluoromethanesulfonate; sulfuric acid; acetic acid; triethylamine; methylamine; In tetrahydrofuran; dichloromethane; water; acetonitrile;

upstream raw materials:

tert-butylchlorodiphenylsilane

((3aR,5R,6S,6aR)-6-(benzyloxy)-5-((benzyloxy)methyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanol

C₄₀H₄₆O₈Si

2'-O-acetyl-3',5'-di-O-benzyl-4'-C-(tert-butyldiphenylsilyloxymethyl)-5-methyluridine

Downstream raw materials:

3',5'-di-O-benzyl-4'-C-(tert-butyldiphenylsilyloxymethyl)-5-methylarabinouridine

C₄₂H₄₅F₃N₂O₉SSi

C₄₁H₄₅N₅O₆Si

C₂₅H₂₇N₅O₆