2-(3,5-bistrifluoromethylphenyl)-N-methyl-N-(2-piperazin-1-yl-5-o-tolylpyrimidin-4-yl)isobutyramide

Base Information

Chemical Name:2-(3,5-bistrifluoromethylphenyl)-N-methyl-N-(2-piperazin-1-yl-5-o-tolylpyrimidin-4-yl)isobutyramide
CAS No.:311335-63-4
Molecular Formula:C₂₈H₂₉F₆N₅O
Molecular Weight:565.562
Hs Code.:

Synonyms:2-(3,5-bistrifluoromethylphenyl)-N-methyl-N-(2-piperazin-1-yl-5-o-tolylpyrimidin-4-yl)isobutyramide

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Chemical Property of 2-(3,5-bistrifluoromethylphenyl)-N-methyl-N-(2-piperazin-1-yl-5-o-tolylpyrimidin-4-yl)isobutyramide

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Technology Process of 2-(3,5-bistrifluoromethylphenyl)-N-methyl-N-(2-piperazin-1-yl-5-o-tolylpyrimidin-4-yl)isobutyramide

There total 4 articles about 2-(3,5-bistrifluoromethylphenyl)-N-methyl-N-(2-piperazin-1-yl-5-o-tolylpyrimidin-4-yl)isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 110-85-0
piperazine

: 311335-61-2
2-(3,5-Bis-trifluoromethyl-phenyl)-N-(2-methanesulfonyl-5-o-tolyl-pyrimidin-4-yl)-N-methyl-isobutyramide

: 311335-63-4
2-(3,5-bistrifluoromethylphenyl)-N-methyl-N-(2-piperazin-1-yl-5-o-tolylpyrimidin-4-yl)isobutyramide

Guidance literature:: In 1,4-dioxane; for 16h;

Reference yield:

: 289686-69-7
2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride

: 311335-63-4
2-(3,5-bistrifluoromethylphenyl)-N-methyl-N-(2-piperazin-1-yl-5-o-tolylpyrimidin-4-yl)isobutyramide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide / 1 h / 0 °C

1.2: 24 h / 20 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 5 - 20 °C

3.1: 1,4-dioxane / 16 h

With potassium hexamethylsilazane; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 2-(3,5-Bis-trifluoromethyl-phenyl)-N-methyl-N-(2-methylsulfanyl-5-o-tolyl-pyrimidin-4-yl)-isobutyramide

: 311335-63-4
2-(3,5-bistrifluoromethylphenyl)-N-methyl-N-(2-piperazin-1-yl-5-o-tolylpyrimidin-4-yl)isobutyramide

Guidance literature:: Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 5 - 20 °C

2: 1,4-dioxane / 16 h

With 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; dichloromethane;