(E)-dimethyl 2-(4-chlorobenzyloxyimino)-3-diazosuccinate

Base Information

• Chemical Name: (E)-dimethyl 2-(4-chlorobenzyloxyimino)-3-diazosuccinate
• CAS No.: 1318796-38-1
• Molecular Formula: C₁₃H₁₂ClN₃O₅
• Molecular Weight: 325.708
• Mol file: 1318796-38-1.mol

Synonyms:(E)-dimethyl 2-(4-chlorobenzyloxyimino)-3-diazosuccinate

Chemical Property of (E)-dimethyl 2-(4-chlorobenzyloxyimino)-3-diazosuccinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-dimethyl 2-(4-chlorobenzyloxyimino)-3-diazosuccinate

There total 3 articles about (E)-dimethyl 2-(4-chlorobenzyloxyimino)-3-diazosuccinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

dimethyl 2-(4-chlorobenzyloxyimino)succinate (1318796-82-5) → (E)-dimethyl 2-(4-chlorobenzyloxyimino)-3-diazosuccinate (1318796-38-1)

Guidance literature:

With p-nitrobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at -20 ℃; for 2h; Inert atmosphere;

DOI:10.1039/c1cc11683e

Reference yield:

Dimethyl 2-oxosuccinate (25007-54-9) → (E)-dimethyl 2-(4-chlorobenzyloxyimino)-3-diazosuccinate (1318796-38-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 3 h / 20 °C / Inert atmosphere

2: p-nitrobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 2 h / -20 °C / Inert atmosphere

With pyridine; p-nitrobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile;

DOI:10.1039/c1cc11683e

Reference yield:

O-(4-chlorobenzyl)hydroxylamine hydrochloride (38936-60-6) → (E)-dimethyl 2-(4-chlorobenzyloxyimino)-3-diazosuccinate (1318796-38-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 3 h / 20 °C / Inert atmosphere

2: p-nitrobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 2 h / -20 °C / Inert atmosphere

With pyridine; p-nitrobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile;

DOI:10.1039/c1cc11683e

upstream raw materials:

dimethyl 2-(4-chlorobenzyloxyimino)succinate

Dimethyl 2-oxosuccinate

O-(4-chlorobenzyl)hydroxylamine hydrochloride

Downstream raw materials:

dimethyl aziridine-2,3-dicarboxylate