((1S,2S,3R,4R)-2-(3-hydroxybenzyl)-4-(tert-butyldimethylsilyloxy)-3-((S)-3-(tert-butyldimethylsilyloxy)octyl)cyclopentyl)methyl 4-methylbenzenesulfonate

Base Information

Chemical Name:((1S,2S,3R,4R)-2-(3-hydroxybenzyl)-4-(tert-butyldimethylsilyloxy)-3-((S)-3-(tert-butyldimethylsilyloxy)octyl)cyclopentyl)methyl 4-methylbenzenesulfonate
CAS No.:1425937-51-4
Molecular Formula:C₄₀H₆₈O₆SSi₂
Molecular Weight:733.213
Hs Code.:

((1S,2S,3R,4R)-2-(3-hydroxybenzyl)-4-(tert-butyldimethylsilyloxy)-3-((S)-3-(tert-butyldimethylsilyloxy)octyl)cyclopentyl)methyl 4-methylbenzenesulfonate

Synonyms:((1S,2S,3R,4R)-2-(3-hydroxybenzyl)-4-(tert-butyldimethylsilyloxy)-3-((S)-3-(tert-butyldimethylsilyloxy)octyl)cyclopentyl)methyl 4-methylbenzenesulfonate

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Chemical Property of ((1S,2S,3R,4R)-2-(3-hydroxybenzyl)-4-(tert-butyldimethylsilyloxy)-3-((S)-3-(tert-butyldimethylsilyloxy)octyl)cyclopentyl)methyl 4-methylbenzenesulfonate

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Technology Process of ((1S,2S,3R,4R)-2-(3-hydroxybenzyl)-4-(tert-butyldimethylsilyloxy)-3-((S)-3-(tert-butyldimethylsilyloxy)octyl)cyclopentyl)methyl 4-methylbenzenesulfonate

There total 15 articles about ((1S,2S,3R,4R)-2-(3-hydroxybenzyl)-4-(tert-butyldimethylsilyloxy)-3-((S)-3-(tert-butyldimethylsilyloxy)octyl)cyclopentyl)methyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1425937-48-9
((1S,2S,3R,4R)-2-(3-(benzyloxy)benzyl)-4-(tert-butyldimethylsilyloxy)-3-((3S)-3-(tert-butyldimethylsilyloxy)octyl)cyclopentyl) methyl 4-methyl benzenesulfonate

: 1425937-51-4
((1S,2S,3R,4R)-2-(3-hydroxybenzyl)-4-(tert-butyldimethylsilyloxy)-3-((S)-3-(tert-butyldimethylsilyloxy)octyl)cyclopentyl)methyl 4-methylbenzenesulfonate

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; potassium hydroxide; In methanol; at 20 ℃; for 2h;

Reference yield: 90.0%

: 1425937-47-8
((1S,2S,3R,4R)-2-(3-(benzyloxy)benzyl)-4-(tert-butyldimethylsilyloxy)-3-((3S,1E)-3-(tert-butyldimethylsilyloxy)oct-1-enyl)cyclopentyl)methyl 4-methylbenzenesulfonate

: 1425937-51-4
((1S,2S,3R,4R)-2-(3-hydroxybenzyl)-4-(tert-butyldimethylsilyloxy)-3-((S)-3-(tert-butyldimethylsilyloxy)octyl)cyclopentyl)methyl 4-methylbenzenesulfonate

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; potassium hydroxide; In methanol; at 20 - 50 ℃; for 7h;

Reference yield:

: 1425937-58-1
(R)-1-(3-(benzyloxy)benzyl)-5-oxo-3-(tert-butyldimethylsilyloxy)cyclopentene

: 1425937-51-4
((1S,2S,3R,4R)-2-(3-hydroxybenzyl)-4-(tert-butyldimethylsilyloxy)-3-((S)-3-(tert-butyldimethylsilyloxy)octyl)cyclopentyl)methyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium; copper(l) cyanide; methyllithium / diethyl ether; hexane; tetrahydrofuran / 0.5 h / -70 °C

1.2: 0.5 h / -70 °C

2.1: zinc; titanium tetrachloride / tetrahydrofuran; dichloromethane / 1.5 h / 25 °C / Cooling with ice

3.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 0 °C / Inert atmosphere

3.2: 1.75 h / 0 - 20 °C

4.1: triethylamine / dichloromethane / 0 °C / Inert atmosphere

5.1: hydrogen; potassium hydroxide; 5%-palladium/activated carbon / methanol / 30 h / 20 - 50 °C

With n-butyllithium; 5%-palladium/activated carbon; methyllithium; hydrogen; copper(l) cyanide; titanium tetrachloride; triethylamine; 9-bora-bicyclo[3.3.1]nonane; potassium hydroxide; zinc; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane;