2-(3-phenyl-6-(trifluoromethyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)thiazole-4-carboxylic acid

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Chemical Name:2-(3-phenyl-6-(trifluoromethyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)thiazole-4-carboxylic acid
CAS No.:1204772-63-3
Molecular Formula:C₁₇H₉F₃N₄O₂S
Molecular Weight:390.345
Hs Code.:

Synonyms:2-(3-phenyl-6-(trifluoromethyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)thiazole-4-carboxylic acid

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Chemical Property of 2-(3-phenyl-6-(trifluoromethyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)thiazole-4-carboxylic acid

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Technology Process of 2-(3-phenyl-6-(trifluoromethyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)thiazole-4-carboxylic acid

There total 3 articles about 2-(3-phenyl-6-(trifluoromethyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)thiazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: ethyl 2-(3-phenyl-6-(trifluoromethyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)thiazole-4-carboxylate

: 1204772-63-3
2-(3-phenyl-6-(trifluoromethyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)thiazole-4-carboxylic acid

Guidance literature:: With sodium hydroxide; In ethanol; water; at 0 ℃; for 4h;
DOI:10.1016/j.bmcl.2018.06.022

Reference yield:

: C₁₃H₈F₃N₃

: 1204772-63-3
2-(3-phenyl-6-(trifluoromethyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)thiazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; potassium phosphate / N,N-dimethyl acetamide / 16 h / 20 - 185 °C

2: sodium hydroxide / water; ethanol / 4 h / 0 °C

With potassium phosphate; copper(l) iodide; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; sodium hydroxide; In ethanol; N,N-dimethyl acetamide; water; 1: |Ullmann Condensation;
DOI:10.1016/j.bmcl.2018.06.022