N-allyl-N-(4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-3-(difluoromethoxy)phenyl)-2-(4-cyclopropylphenoxy)but-2-enamide

Base Information

Chemical Name:N-allyl-N-(4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-3-(difluoromethoxy)phenyl)-2-(4-cyclopropylphenoxy)but-2-enamide
CAS No.:1574541-97-1
Molecular Formula:C₃₁H₄₁F₂NO₅Si
Molecular Weight:573.753
Hs Code.:

Synonyms:N-allyl-N-(4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-3-(difluoromethoxy)phenyl)-2-(4-cyclopropylphenoxy)but-2-enamide

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Chemical Property of N-allyl-N-(4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-3-(difluoromethoxy)phenyl)-2-(4-cyclopropylphenoxy)but-2-enamide

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Technology Process of N-allyl-N-(4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-3-(difluoromethoxy)phenyl)-2-(4-cyclopropylphenoxy)but-2-enamide

There total 9 articles about N-allyl-N-(4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-3-(difluoromethoxy)phenyl)-2-(4-cyclopropylphenoxy)but-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1574541-96-0
N-(4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-3-(difluoromethoxy)phenyl)-2-(4-cyclopropylphenoxy)but-2-enamide

: 106-95-6
allyl bromide

: 1574541-97-1
N-allyl-N-(4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-3-(difluoromethoxy)phenyl)-2-(4-cyclopropylphenoxy)but-2-enamide

Guidance literature:: N-(4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-3-(difluoromethoxy)phenyl)-2-(4-cyclopropylphenoxy)but-2-enamide; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

allyl bromide; In N,N-dimethyl-formamide;

Reference yield:

: 1574541-77-7
methyl 2-(4-cyclopropylphenoxy)but-2-enoate

: 1574541-97-1
N-allyl-N-(4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-3-(difluoromethoxy)phenyl)-2-(4-cyclopropylphenoxy)but-2-enamide

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide monohydrate; water / tetrahydrofuran / 0 - 20 °C

2: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 16 h

3: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

With lithium hydroxide monohydrate; water; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1574541-93-7
2-(2-(difluoromethoxy)-4-nitrophenoxy)ethanol

: 1574541-97-1
N-allyl-N-(4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-3-(difluoromethoxy)phenyl)-2-(4-cyclopropylphenoxy)but-2-enamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1H-imidazole / dichloromethane / 1.17 h / 0 - 20 °C

2: 5%-palladium/activated carbon; ammonium formate / ethanol / 0.33 h

3: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 16 h

4: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

With 1H-imidazole; 5%-palladium/activated carbon; ammonium formate; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;