(2,4-dihydroxy-3-(3-methylbut-2-enyl)phenyl)(6-hydroxybenzofuran-2-yl)methanone

Base Information

• Chemical Name: (2,4-dihydroxy-3-(3-methylbut-2-enyl)phenyl)(6-hydroxybenzofuran-2-yl)methanone
• CAS No.: 1304030-91-8
• Molecular Formula: C₂₀H₁₈O₅
• Molecular Weight: 338.36
• Mol file: 1304030-91-8.mol

Synonyms:(2,4-dihydroxy-3-(3-methylbut-2-enyl)phenyl)(6-hydroxybenzofuran-2-yl)methanone

Chemical Property of (2,4-dihydroxy-3-(3-methylbut-2-enyl)phenyl)(6-hydroxybenzofuran-2-yl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2,4-dihydroxy-3-(3-methylbut-2-enyl)phenyl)(6-hydroxybenzofuran-2-yl)methanone

There total 7 articles about (2,4-dihydroxy-3-(3-methylbut-2-enyl)phenyl)(6-hydroxybenzofuran-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(2-hydroxy-4-(methoxymethoxy)-3-[3-methylbut-2-enyl]phenyl)(6-(methoxymethoxybenzofuran-2-yl))methanone → (2,4-dihydroxy-3-(3-methylbut-2-enyl)phenyl)(6-hydroxybenzofuran-2-yl)methanone (1304030-91-8)

Guidance literature:

With sulfuric acid; In tetrahydrofuran; isopropyl alcohol; at 0 - 20 ℃; for 3h;

DOI:10.1002/jccs.201800261

Reference yield:

2-Bromo-2',4'-dimethoxyacetophenone (60965-26-6) → (2,4-dihydroxy-3-(3-methylbut-2-enyl)phenyl)(6-hydroxybenzofuran-2-yl)methanone (1304030-91-8)

Guidance literature:

Multi-step reaction with 6 steps

1: potassium carbonate / acetone / 20 h / Reflux

2: boron tribromide / dichloromethane / 40 h / 0 - 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

4: potassium carbonate / acetone / Reflux

5: montmorillonite K₁₀ / dichloromethane / 2 h / 0 °C

6: sulfuric acid / tetrahydrofuran; isopropyl alcohol / 3 h / 0 - 20 °C

With sulfuric acid; boron tribromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; isopropyl alcohol; acetone; 1: |Rapp-Stoermer Benzofuran Synthesis;

DOI:10.1002/jccs.201800261

Reference yield:

(6-hydroxybenzofuran-2-yl)(2,4-dihydroxyphenyl)methanone → (2,4-dihydroxy-3-(3-methylbut-2-enyl)phenyl)(6-hydroxybenzofuran-2-yl)methanone (1304030-91-8)

Guidance literature:

Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

2: potassium carbonate / acetone / Reflux

3: montmorillonite K₁₀ / dichloromethane / 2 h / 0 °C

4: sulfuric acid / tetrahydrofuran; isopropyl alcohol / 3 h / 0 - 20 °C

With sulfuric acid; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; isopropyl alcohol; acetone;

DOI:10.1002/jccs.201800261

upstream raw materials:

2-Bromo-2',4'-dimethoxyacetophenone

2-Hydroxy-4-methoxybenzaldehyde

Downstream raw materials:

(2,4-dihydroxy-3-[2-hydroxy-3-methylbut-3-enyl]phenyl)(6-hydroxybenzofuran-2-yl)methanone