N-[4-cyano-2-(trifluoromethoxy)phenyl]acetamide

Base Information

Chemical Name:N-[4-cyano-2-(trifluoromethoxy)phenyl]acetamide
CAS No.:175278-19-0
Molecular Formula:C10H7 F3 N2 O2
Molecular Weight:244.173
Hs Code.:2926907090
DSSTox Substance ID:DTXSID00371565
Wikidata:Q82158930
Mol file:175278-19-0.mol

Synonyms:175278-19-0;N-[4-cyano-2-(trifluoromethoxy)phenyl]acetamide;4-Cyano-2-(trifluoromethoxy)acetanilide;N-(4-Cyano-2-(trifluoromethoxy)phenyl)acetamide;Acetamide, N-[4-cyano-2-(trifluoromethoxy)phenyl]-;4'-Cyano-2'-(trifluoromethoxy)acetanilide;Maybridge1_000083;MixCom1_000149;N1-[4-cyano-2-(trifluoromethoxy)phenyl]acetamide;SCHEMBL4398648;DTXSID00371565;MFCD00204174;AKOS022181786;FS-1070;CS-0333838;FT-0629701;N-(4-cyano-2-trifluoromethoxyphenyl)-acetamide;A881591;4-cyano-2-(trifluoromethoxy)acetanilide, AldrichCPR

Suppliers and Price of N-[4-cyano-2-(trifluoromethoxy)phenyl]acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Cyano-2-(trifluoromethoxy)acetanilide
1g
$ 130.00

TRC
4-Cyano-2-(trifluoromethoxy)acetanilide
100mg
$ 45.00

Matrix Scientific
4-Cyano-2-(trifluoromethoxy)acetanilide 97%
5g
$ 153.00

Matrix Scientific
4-Cyano-2-(trifluoromethoxy)acetanilide 97%
1g
$ 40.00

Crysdot
N-(4-Cyano-2-(trifluoromethoxy)phenyl)acetamide 97%
10g
$ 380.00

American Custom Chemicals Corporation
4-CYANO-2-(TRIFLUOROMETHOXY)ACETANILIDE 95.00%
5G
$ 918.23

American Custom Chemicals Corporation
4-CYANO-2-(TRIFLUOROMETHOXY)ACETANILIDE 95.00%
1G
$ 621.39

Alichem
N-(4-Cyano-2-(trifluoromethoxy)phenyl)acetamide
10g
$ 418.56

AK Scientific
4-Cyano-2-(trifluoromethoxy)acetanilide
5g
$ 156.00

AK Scientific
4-Cyano-2-(trifluoromethoxy)acetanilide
1g
$ 75.00

Total 14 raw suppliers

Chemical Property of N-[4-cyano-2-(trifluoromethoxy)phenyl]acetamide

Chemical Property:

Vapor Pressure:0.000223mmHg at 25°C
Melting Point:118 °C
Refractive Index:1.492
Boiling Point:325.9°C at 760 mmHg
Flash Point:150.9°C
PSA：62.12000
Density:1.38g/cm³
LogP:2.48828
Storage Temp.:2-8°C
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:244.04596196
Heavy Atom Count:17
Complexity:334

Purity/Quality:

97% ^*data from raw suppliers

4-Cyano-2-(trifluoromethoxy)acetanilide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi,Xn
Statements: 36/37/38-43-36-22
Safety Statements: 26-36-36/37

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)NC1=C(C=C(C=C1)C#N)OC(F)(F)F

Technology Process of N-[4-cyano-2-(trifluoromethoxy)phenyl]acetamide

There total 4 articles about N-[4-cyano-2-(trifluoromethoxy)phenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: N-(4-cyanophenyl)-N-(trifluoromethoxy)acetamide

: 175278-19-0
N-(4-cyano-2-(trifluoromethoxy)phenyl)acetamide

Guidance literature:: In nitromethane; at 120 ℃; for 48h; Inert atmosphere;
DOI:10.1002/anie.201409375

Reference yield:

: 619-72-7
4-nitrobenzonitrile

: 175278-19-0
N-(4-cyano-2-(trifluoromethoxy)phenyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrate; 5% rhodium-on-charcoal / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere

2: sodium hydrogencarbonate / diethyl ether / 0 °C / Inert atmosphere

3: caesium carbonate / chloroform / 23 h / 20 °C / Inert atmosphere

4: nitromethane / 48 h / 120 °C / Inert atmosphere

With 5% rhodium-on-charcoal; sodium hydrogencarbonate; caesium carbonate; hydrazine hydrate; In tetrahydrofuran; diethyl ether; nitromethane; chloroform;
DOI:10.1002/anie.201409375

Reference yield:

: 80584-65-2
N-(4-cyanophenyl)acetohydroxamic acid

: 175278-19-0
N-(4-cyano-2-(trifluoromethoxy)phenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / chloroform / 23 h / 20 °C / Inert atmosphere

2: nitromethane / 48 h / 120 °C / Inert atmosphere

With caesium carbonate; In nitromethane; chloroform;
DOI:10.1002/anie.201409375