6α-hydroxy-7α-hydroxymethyl-7β,9-dimethyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole

Base Information

Chemical Name:6α-hydroxy-7α-hydroxymethyl-7β,9-dimethyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole
CAS No.:142502-21-4
Molecular Formula:C₂₅H₂₇NO₄S
Molecular Weight:437.56
Hs Code.:

Synonyms:6α-hydroxy-7α-hydroxymethyl-7β,9-dimethyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole

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Chemical Property of 6α-hydroxy-7α-hydroxymethyl-7β,9-dimethyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole

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Technology Process of 6α-hydroxy-7α-hydroxymethyl-7β,9-dimethyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole

There total 3 articles about 6α-hydroxy-7α-hydroxymethyl-7β,9-dimethyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 142502-20-3
7β,9-dimethyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole-7α,6α-carbolactone

: 142502-21-4
6α-hydroxy-7α-hydroxymethyl-7β,9-dimethyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Ambient temperature;
DOI:10.1016/0223-5234(92)90100-F

Reference yield:

: 142502-19-0
9-methyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole-7α,6α-carbolactone

: 142502-21-4
6α-hydroxy-7α-hydroxymethyl-7β,9-dimethyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, hexane, -78 deg C, 10 min, 2.) THF, hexane, RT, 2 h

2: 45 percent / LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

With lithium aluminium tetrahydride; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1016/0223-5234(92)90100-F

Reference yield:

: 131938-81-3
(6aR,7S,10aR)-9-Methyl-6-oxo-5-(toluene-4-sulfonyl)-5,6,6a,7,8,10a-hexahydro-indeno[2,1-b]indole-7-carboxylic acid methyl ester

: 142502-21-4
6α-hydroxy-7α-hydroxymethyl-7β,9-dimethyl-5-tosyl-5,6β,6aβ,7β,8,10aβ-hexahydroindeno<2,1-b>indole

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / NaBH₄ / tetrahydrofuran; methanol / 1.) -10 deg C, 15 min, 2.) RT, 2 h

2: 1.) LDA / 1.) THF, hexane, -78 deg C, 10 min, 2.) THF, hexane, RT, 2 h

3: 45 percent / LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

With sodium tetrahydroborate; lithium aluminium tetrahydride; lithium diisopropyl amide; In tetrahydrofuran; methanol;
DOI:10.1016/0223-5234(92)90100-F