Technology Process of 2,6-dibenzyloxyisonicotinic acid
There total 1 articles about 2,6-dibenzyloxyisonicotinic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2,6-dichloropyridine-4-carboxylic acid; benzyl alcohol;
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 80 ℃;
for 4h;
Inert atmosphere;
Cooling;
With
acetic acid;
In
water;
- Guidance literature:
-
With
thionyl chloride;
N,N-dimethyl-formamide;
In
toluene;
at 80 ℃;
for 4.5h;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: thionyl chloride / N,N-dimethyl-formamide / toluene / 4.5 h / 80 °C
2: triethylamine / 1,4-dioxane / 8 h / 20 °C / Cooling with ice
3: hydrogen / palladium(II) hydroxide / 1,4-dioxane / 1 h
4: pyridine / 1,2-dimethoxyethane / 0.5 h / Cooling with ice
With
pyridine; thionyl chloride; hydrogen; triethylamine;
palladium(II) hydroxide; N,N-dimethyl-formamide;
In
1,4-dioxane; 1,2-dimethoxyethane; toluene;
