N-{[(6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}methanesulfonamide monohydrochloride

Base Information

Chemical Name:N-{[(6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}methanesulfonamide monohydrochloride
CAS No.:1372179-96-8
Molecular Formula:C₁₃H₁₈Cl₂N₂O₃S*ClH
Molecular Weight:389.73
Hs Code.:

Synonyms:N-{[(6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}methanesulfonamide monohydrochloride

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Chemical Property of N-{[(6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}methanesulfonamide monohydrochloride

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Technology Process of N-{[(6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}methanesulfonamide monohydrochloride

There total 13 articles about N-{[(6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}methanesulfonamide monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1372186-99-6
tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-{[(methylsulfonyl)amino]methyl}-1,4-oxazepane-4-carboxylate

: 1372179-96-8
N-{[(6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}methanesulfonamide monohydrochloride

Guidance literature:: With hydrogenchloride; In ethanol; at 10 - 35 ℃; for 2h;

Reference yield:

: 1372189-39-3
tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-(hydroxymethyl)-1,4-oxazepane-4-carboxylate

: 1372179-96-8
N-{[(6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}methanesulfonamide monohydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / tetrahydrofuran / 2 h / Cooling with ice

2: sodium azide / N,N-dimethyl-formamide / 70 °C

3: triphenylphosphine; water / tetrahydrofuran / 10 - 35 °C

4: triethylamine / 1 h / Cooling with ice

5: hydrogenchloride / ethanol / 2 h / 10 - 35 °C

With hydrogenchloride; sodium azide; water; triethylamine; triphenylphosphine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; 3: Staudinger Reaction;

Reference yield:

: 1372186-95-2
tert-butyl (6S,7R)-6-(azidomethyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate

: 1372179-96-8
N-{[(6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}methanesulfonamide monohydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; water / tetrahydrofuran / 10 - 35 °C

2: triethylamine / 1 h / Cooling with ice

3: hydrogenchloride / ethanol / 2 h / 10 - 35 °C

With hydrogenchloride; water; triethylamine; triphenylphosphine; In tetrahydrofuran; ethanol; 1: Staudinger Reaction;