9-(5-O-dimethoxytrityl-2-deoxy-β-D-erythro-pentofuranose)-6-(1,2,4-triazol-4-yl)purine

Base Information

• Chemical Name: 9-(5-O-dimethoxytrityl-2-deoxy-β-D-erythro-pentofuranose)-6-(1,2,4-triazol-4-yl)purine
• CAS No.: 244639-79-0
• Molecular Formula: C₃₃H₃₁N₇O₅
• Molecular Weight: 605.653

Synonyms:9-(5-O-dimethoxytrityl-2-deoxy-β-D-erythro-pentofuranose)-6-(1,2,4-triazol-4-yl)purine

Chemical Property of 9-(5-O-dimethoxytrityl-2-deoxy-β-D-erythro-pentofuranose)-6-(1,2,4-triazol-4-yl)purine

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Technology Process of 9-(5-O-dimethoxytrityl-2-deoxy-β-D-erythro-pentofuranose)-6-(1,2,4-triazol-4-yl)purine

There total 3 articles about 9-(5-O-dimethoxytrityl-2-deoxy-β-D-erythro-pentofuranose)-6-(1,2,4-triazol-4-yl)purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + 9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-(1,2,4-triazol-4-yl)purine (163632-55-1) → 9-(5-O-dimethoxytrityl-2-deoxy-β-D-erythro-pentofuranose)-6-(1,2,4-triazol-4-yl)purine (244639-79-0)

Guidance literature:

With pyridine; for 6h;

DOI:10.1080/07328319908044615

Reference yield:

2'-deoxy-D-adenosine (958-09-8,7005-15-4) → 9-(5-O-dimethoxytrityl-2-deoxy-β-D-erythro-pentofuranose)-6-(1,2,4-triazol-4-yl)purine (244639-79-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ClSiMe₃; pyridine / 21 h

1.2: 62 percent / methanol / 6 h / Heating

2.1: pyridine

With pyridine; chloro-trimethyl-silane;

DOI:10.1023/B:RUBI.0000030129.13466.18

Reference yield:

9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-(1,2,4-triazol-4-yl)purine (163632-55-1) → 9-(5-O-dimethoxytrityl-2-deoxy-β-D-erythro-pentofuranose)-6-(1,2,4-triazol-4-yl)purine (244639-79-0)

Guidance literature:

DOI:10.1080/07328319908044749

upstream raw materials:

4,4'-dimethoxytrityl chloride

9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-(1,2,4-triazol-4-yl)purine

2'-deoxy-D-adenosine

Downstream raw materials:

5'-O-dimethoxytrityl-6-N-(4,9,13-triazatridecane-1-yl)-2'-deoxyadenosine

5'-O-dimethoxytrityl-6-N-[tris(N,N',N-trifluoroacetyl)-4,9,13-triazadecane-1-yl]-2'-deoxyadenosine

N⁶-{3-[N,N-bis(2-methoxyoxalylaminoathyl)aminoethyl]aminooxalylaminopropyl}-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine

N⁶-(3-aminopropyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine

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