(S)-methyl 3-hydroxy-2-(4-((4-methoxy-2,3,6-trimethylphenylsulfonamido)methyl) benzylamino)propanoate

Base Information

Chemical Name:(S)-methyl 3-hydroxy-2-(4-((4-methoxy-2,3,6-trimethylphenylsulfonamido)methyl) benzylamino)propanoate
CAS No.:1414915-85-7
Molecular Formula:C₂₂H₃₀N₂O₆S
Molecular Weight:450.556
Hs Code.:

Synonyms:(S)-methyl 3-hydroxy-2-(4-((4-methoxy-2,3,6-trimethylphenylsulfonamido)methyl) benzylamino)propanoate

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Chemical Property of (S)-methyl 3-hydroxy-2-(4-((4-methoxy-2,3,6-trimethylphenylsulfonamido)methyl) benzylamino)propanoate

Chemical Property:

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Technology Process of (S)-methyl 3-hydroxy-2-(4-((4-methoxy-2,3,6-trimethylphenylsulfonamido)methyl) benzylamino)propanoate

There total 3 articles about (S)-methyl 3-hydroxy-2-(4-((4-methoxy-2,3,6-trimethylphenylsulfonamido)methyl) benzylamino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39895-56-2
4-hydroxymethyl-benzylamine

: 1414915-85-7
(S)-methyl 3-hydroxy-2-(4-((4-methoxy-2,3,6-trimethylphenylsulfonamido)methyl) benzylamino)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 6.5 h / 0 - 20 °C / Inert atmosphere

2: manganese(IV) oxide / tetrahydrofuran / Inert atmosphere

3: triethylamine; sodium triacetoxyborohydride / tetrahydrofuran / 5 h / 25 °C / Inert atmosphere

With manganese(IV) oxide; sodium triacetoxyborohydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1021/jm301058f

Reference yield:

: 1414915-83-5
4-((4-methoxy-2,3,6-trimethylphenylsulfonyl)aminomethyl)benzaldehyde

: 5680-80-8
methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride

: 1414915-85-7
(S)-methyl 3-hydroxy-2-(4-((4-methoxy-2,3,6-trimethylphenylsulfonamido)methyl) benzylamino)propanoate

Guidance literature:: With sodium triacetoxyborohydride; triethylamine; In tetrahydrofuran; at 25 ℃; for 5h; Inert atmosphere;
DOI:10.1021/jm301058f

Reference yield:

: 56-91-7
p-aminomethylbenzoic acid

: 1414915-85-7
(S)-methyl 3-hydroxy-2-(4-((4-methoxy-2,3,6-trimethylphenylsulfonamido)methyl) benzylamino)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Reflux

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 6.5 h / 0 - 20 °C / Inert atmosphere

3: manganese(IV) oxide / tetrahydrofuran / Inert atmosphere

4: triethylamine; sodium triacetoxyborohydride / tetrahydrofuran / 5 h / 25 °C / Inert atmosphere

With manganese(IV) oxide; lithium aluminium tetrahydride; sodium triacetoxyborohydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1021/jm301058f