(3aR,4S,6R,6aS)-6-(3-(4-methoxybenzyl)-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-tetrahydro-2,2-dimethylfuro[3,4-d][1,3]dioxole-4-carbaldehyde

Base Information

Chemical Name:(3aR,4S,6R,6aS)-6-(3-(4-methoxybenzyl)-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-tetrahydro-2,2-dimethylfuro[3,4-d][1,3]dioxole-4-carbaldehyde
CAS No.:121845-98-5
Molecular Formula:C₂₀H₂₂N₂O₇
Molecular Weight:402.404
Hs Code.:

Synonyms:(3aR,4S,6R,6aS)-6-(3-(4-methoxybenzyl)-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-tetrahydro-2,2-dimethylfuro[3,4-d][1,3]dioxole-4-carbaldehyde

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3aR,4S,6R,6aS)-6-(3-(4-methoxybenzyl)-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-tetrahydro-2,2-dimethylfuro[3,4-d][1,3]dioxole-4-carbaldehyde

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of (3aR,4S,6R,6aS)-6-(3-(4-methoxybenzyl)-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-tetrahydro-2,2-dimethylfuro[3,4-d][1,3]dioxole-4-carbaldehyde

There total 7 articles about (3aR,4S,6R,6aS)-6-(3-(4-methoxybenzyl)-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-tetrahydro-2,2-dimethylfuro[3,4-d][1,3]dioxole-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 32464-93-0
1-(2,3-O-Isopropylidene-β-D-ribofuranosyl)-3-(4-methoxybenzyl)uracil

: 121845-98-5
(3aR,4S,6R,6aS)-6-(3-(4-methoxybenzyl)-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-tetrahydro-2,2-dimethylfuro[3,4-d][1,3]dioxole-4-carbaldehyde

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1039/b819155g

Reference yield:

: 362-43-6
2',3'-O-isopropylideneuridine

: 121845-98-5
(3aR,4S,6R,6aS)-6-(3-(4-methoxybenzyl)-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-tetrahydro-2,2-dimethylfuro[3,4-d][1,3]dioxole-4-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / triethylamine / CH₂Cl₂ / 0.08 h / Ambient temperature

2: NaH / dimethylformamide / 0.17 h / 0 °C

3: K₂CO₃ / methanol / 2 h / Ambient temperature

4: 79 percent / dimethyl sulfoxide, trifluoroacetic acid, pyridine, dicyclohexylcarbodiimide / benzene / 6 h / 5 °C

With pyridine; sodium hydride; potassium carbonate; dimethyl sulfoxide; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ja00197a047

Reference yield:

: 15922-23-3
1-(5-O-Acetyl-2,3-O-isopropylidene-β-D-ribofuranosyl)uracil

: 121845-98-5
(3aR,4S,6R,6aS)-6-(3-(4-methoxybenzyl)-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-tetrahydro-2,2-dimethylfuro[3,4-d][1,3]dioxole-4-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: NaH / dimethylformamide / 0.17 h / 0 °C

2: K₂CO₃ / methanol / 2 h / Ambient temperature

3: 79 percent / dimethyl sulfoxide, trifluoroacetic acid, pyridine, dicyclohexylcarbodiimide / benzene / 6 h / 5 °C

With pyridine; sodium hydride; potassium carbonate; dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; In methanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ja00197a047