D-1,3,6-tri-O-benzyl-2,4,5-tris-O-[di(benzyloxy)phosphoryl]-myo-inositol

Base Information

• Chemical Name: D-1,3,6-tri-O-benzyl-2,4,5-tris-O-[di(benzyloxy)phosphoryl]-myo-inositol
• CAS No.: 115510-57-1
• Molecular Formula: C₆₉H₆₉O₁₅P₃
• Molecular Weight: 1231.22
• Mol file: 115510-57-1.mol

Synonyms:D-1,3,6-tri-O-benzyl-2,4,5-tris-O-[di(benzyloxy)phosphoryl]-myo-inositol

Chemical Property of D-1,3,6-tri-O-benzyl-2,4,5-tris-O-[di(benzyloxy)phosphoryl]-myo-inositol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of D-1,3,6-tri-O-benzyl-2,4,5-tris-O-[di(benzyloxy)phosphoryl]-myo-inositol

There total 55 articles about D-1,3,6-tri-O-benzyl-2,4,5-tris-O-[di(benzyloxy)phosphoryl]-myo-inositol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate (990-91-0) + (+/-)-2,5,6-tri-O-benzyl-myo-inositol (98906-30-0,104873-76-9,111466-07-0,114297-88-0,114297-91-5,114419-08-8,115184-71-9,115509-75-6,115509-76-7,118354-54-4,118354-55-5,128163-34-8,129706-80-5,136521-84-1,149713-88-2,149713-95-1) → DL-2,5,6-tri-O-benzyl-1,3,4-tris(dibenzylphospho)-myo-inositol (114342-70-0,114419-09-9,115184-72-0,115184-73-1,115510-57-1,115510-58-2,116907-55-2,118354-52-2,118396-24-0,129783-87-5)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃;

DOI:10.1016/S0040-4020(01)89510-7

Reference yield: 73.0%

(±)-1,3,6-tri-O-benzyl-myo-inositol (98906-30-0,104873-76-9,111466-07-0,114297-88-0,114297-91-5,114419-08-8,115184-71-9,115509-76-7,118354-54-4,118354-55-5,128163-34-8,129706-80-5,136521-84-1,149713-88-2,149713-95-1,115509-75-6) + Dibenzyl N,N-diisopropylphosphoramidite (108549-23-1) → D-1,3,6-tri-O-benzyl-2,4,5-tris-O-[di(benzyloxy)phosphoryl]-myo-inositol (115510-57-1)

Guidance literature:

(±)-1,3,6-tri-O-benzyl-myo-inositol; Dibenzyl N,N-diisopropylphosphoramidite; With 1H-tetrazole; In dichloromethane; at 20 ℃; for 0.25h;

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -78 - 20 ℃; for 0.5h;

DOI:10.1016/S0008-6215(02)00289-6

Reference yield: 73.0%

Phosphorous acid dibenzyl ester (1R,2S,3S,4R,5R,6R)-2,3,6-tris-benzyloxy-4,5-bis-(bis-benzyloxy-phosphanyloxy)-cyclohexyl ester → DL-2,5,6-tri-O-benzyl-1,3,4-tris(dibenzylphospho)-myo-inositol (114342-70-0,114419-09-9,115184-72-0,115184-73-1,115510-57-1,115510-58-2,116907-55-2,118354-52-2,118396-24-0,129783-87-5)

Guidance literature:

With tert.-butylhydroperoxide; 1.) overnight, 2.) ethanol, RT, 15 min;

DOI:10.1021/jm00049a011

upstream raw materials:

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

(1R,2R,3S,4R,5R,6R)-3,5,6-Tris-benzyloxy-cyclohexane-1,2,4-triol

C₃₉H₅₄O₁₂

(±)-2,3,6-tri-O-benzyl-myo-inositol

Downstream raw materials:

D-myo-inositol 2,4,5-trisphosphate

(+/-)-myo-inositol-1,3,4-trisphosphate

(+/-)-myo-inositol-2,4,5-trisphosphate

(+/-)-D-myo-inositol 1,4,5-tris(phosphate)