N-(2-{[6-(4-fluorophenoxy)pyrazin-2-yl]methylamino}ethyl)-N-methylacetamide

Base Information

Chemical Name:N-(2-{[6-(4-fluorophenoxy)pyrazin-2-yl]methylamino}ethyl)-N-methylacetamide
CAS No.:1448689-05-1
Molecular Formula:C₁₆H₁₉FN₄O₂
Molecular Weight:318.351
Hs Code.:

Synonyms:N-(2-{[6-(4-fluorophenoxy)pyrazin-2-yl]methylamino}ethyl)-N-methylacetamide

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Chemical Property of N-(2-{[6-(4-fluorophenoxy)pyrazin-2-yl]methylamino}ethyl)-N-methylacetamide

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Technology Process of N-(2-{[6-(4-fluorophenoxy)pyrazin-2-yl]methylamino}ethyl)-N-methylacetamide

There total 3 articles about N-(2-{[6-(4-fluorophenoxy)pyrazin-2-yl]methylamino}ethyl)-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1448692-33-8
C₁₄H₁₇FN₄O

: 108-24-7
acetic anhydride

: 1448689-05-1
N-(2-{[6-(4-fluorophenoxy)pyrazin-2-yl]methylamino}ethyl)-N-methylacetamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 15h;

Reference yield:

: 1178459-66-9
2-chloro-6-(4-fluorophenoxy)pyrazine

: 1448689-05-1
N-(2-{[6-(4-fluorophenoxy)pyrazin-2-yl]methylamino}ethyl)-N-methylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: cesium fluoride / dimethyl sulfoxide / 12 h / 120 °C

2: triethylamine / dichloromethane / 15 h / 20 °C

With triethylamine; cesium fluoride; In dichloromethane; dimethyl sulfoxide;

Reference yield:

: 371-41-5
4-Fluorophenol

: 1448689-05-1
N-(2-{[6-(4-fluorophenoxy)pyrazin-2-yl]methylamino}ethyl)-N-methylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / 1,4-dioxane; paraffin oil / 18.5 h / 20 - 100 °C / Inert atmosphere

2: cesium fluoride / dimethyl sulfoxide / 12 h / 120 °C

3: triethylamine / dichloromethane / 15 h / 20 °C

With sodium hydride; triethylamine; cesium fluoride; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide; paraffin oil;