(1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (E)-2-tridecen-7-ynoate

Base Information

Chemical Name:(1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (E)-2-tridecen-7-ynoate
CAS No.:259733-32-9
Molecular Formula:C₂₉H₄₂O₂
Molecular Weight:422.651
Hs Code.:

Synonyms:(1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (E)-2-tridecen-7-ynoate

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Chemical Property of (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (E)-2-tridecen-7-ynoate

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Technology Process of (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (E)-2-tridecen-7-ynoate

There total 5 articles about (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (E)-2-tridecen-7-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (E)-2-Methyl-tridec-2-en-7-ynoyl chloride

: 65253-04-5
(-)-8-phenylmenthol

: 259733-32-9
(1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (E)-2-tridecen-7-ynoate

Guidance literature:: (-)-8-phenylmenthol; With n-butyllithium; In tetrahydrofuran; hexane; at 20 ℃; for 1.5h;

(E)-2-Methyl-tridec-2-en-7-ynoyl chloride; In tetrahydrofuran; hexane; at 20 ℃; Further stages.;
DOI:10.1021/ol9904038

Reference yield:

: (E)-2-Methyl-tridec-2-en-7-ynoic acid

: 259733-32-9
(1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (E)-2-tridecen-7-ynoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: (COCl)2 / benzene / 70 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 1.5 h / 20 °C

2.2: tetrahydrofuran; hexane / 20 °C

With n-butyllithium; oxalyl dichloride; In tetrahydrofuran; hexane; benzene; 1.1: Chlorination / 2.1: Metallation / 2.2: Esterification;
DOI:10.1021/ol9904038

Reference yield:

: 69222-09-9
undec-5-yn-1-ol

: 259733-32-9
(1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (E)-2-tridecen-7-ynoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: SO₃*Py; DMSO; Et₃N / CH₂Cl₂ / 20 °C

2.1: NaH / tetrahydrofuran / 0.17 h / 20 °C

2.2: tetrahydrofuran / 20 °C

3.1: KOH / ethanol; diethyl ether / Heating

4.1: (COCl)2 / benzene / 70 °C

5.1: n-BuLi / tetrahydrofuran; hexane / 1.5 h / 20 °C

5.2: tetrahydrofuran; hexane / 20 °C

With potassium hydroxide; n-butyllithium; oxalyl dichloride; pyridine-SO₃ complex; sodium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; diethyl ether; ethanol; hexane; dichloromethane; benzene; 1.1: Oxidation / 2.1: Metallation / 2.2: Condensation / 3.1: saponification / 4.1: Chlorination / 5.1: Metallation / 5.2: Esterification;
DOI:10.1021/ol9904038