methyl 4-(3,5-dichloro-4-ethoxybenzamido)-2-chlorobenzoate

Base Information

• Chemical Name: methyl 4-(3,5-dichloro-4-ethoxybenzamido)-2-chlorobenzoate
• CAS No.: 1272526-98-3
• Molecular Formula: C₁₇H₁₄Cl₃NO₄
• Molecular Weight: 402.661
• Mol file: 1272526-98-3.mol

Synonyms:methyl 4-(3,5-dichloro-4-ethoxybenzamido)-2-chlorobenzoate

Chemical Property of methyl 4-(3,5-dichloro-4-ethoxybenzamido)-2-chlorobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-(3,5-dichloro-4-ethoxybenzamido)-2-chlorobenzoate

There total 4 articles about methyl 4-(3,5-dichloro-4-ethoxybenzamido)-2-chlorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

→ methyl 4-(3,5-dichloro-4-ethoxybenzamido)-2-chlorobenzoate (1272526-98-3)

Guidance literature:

Reference yield:

methyl 4-amino-2-chlorobenzoate (46004-37-9) + 3,5-dichloro-4-ethoxy-benzoyl chloride (41490-21-5) → methyl 4-(3,5-dichloro-4-ethoxybenzamido)-2-chlorobenzoate (1272526-98-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 12h;

DOI:10.1016/j.bmc.2017.12.015

Reference yield:

3,5-dichloro-4-ethoxybenzoic acid (41490-08-8) → methyl 4-(3,5-dichloro-4-ethoxybenzamido)-2-chlorobenzoate (1272526-98-3)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 0 - 25 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 25 °C

With oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1016/j.bmc.2017.12.015

upstream raw materials:

3,5-dichloro-4-ethoxybenzoic acid

methyl 4-amino-2-chlorobenzoate

3,5-dichloro-4-ethoxy-benzoyl chloride

methyl 3,5-dichloro-4-hydroxybenzoate

Downstream raw materials:

2-chloro-4-(3,5-dichloro-4-ethoxybenzamido)benzoic acid