2-{2-[3-(4-o-Tolyl-piperazin-1-yl)-propoxy]-phenyl}-thiazolidine-3-carbothioic acid methylamide

Base Information

Chemical Name:2-{2-[3-(4-o-Tolyl-piperazin-1-yl)-propoxy]-phenyl}-thiazolidine-3-carbothioic acid methylamide
CAS No.:103074-40-4
Molecular Formula:C₂₅H₃₄N₄OS₂
Molecular Weight:470.703
Hs Code.:

Synonyms:2-{2-[3-(4-o-Tolyl-piperazin-1-yl)-propoxy]-phenyl}-thiazolidine-3-carbothioic acid methylamide

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Chemical Property of 2-{2-[3-(4-o-Tolyl-piperazin-1-yl)-propoxy]-phenyl}-thiazolidine-3-carbothioic acid methylamide

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Technology Process of 2-{2-[3-(4-o-Tolyl-piperazin-1-yl)-propoxy]-phenyl}-thiazolidine-3-carbothioic acid methylamide

There total 3 articles about 2-{2-[3-(4-o-Tolyl-piperazin-1-yl)-propoxy]-phenyl}-thiazolidine-3-carbothioic acid methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 39512-51-1
1-(o-toluyl)piperazine

: 103076-37-5
2-[2-(3-Chloro-propoxy)-phenyl]-thiazolidine-3-carbothioic acid methylamide

: 103074-40-4
2-{2-[3-(4-o-Tolyl-piperazin-1-yl)-propoxy]-phenyl}-thiazolidine-3-carbothioic acid methylamide

Guidance literature:: With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 20h;
DOI:10.1248/cpb.35.2394

Reference yield:

: 54373-12-5
2-(3-chloropropoxy)benzaldehyde

: 103074-40-4
2-{2-[3-(4-o-Tolyl-piperazin-1-yl)-propoxy]-phenyl}-thiazolidine-3-carbothioic acid methylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent

2: 91 percent / K₂CO₃/NaI / dimethylformamide / 20 h / 80 °C

With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.35.2394

Reference yield:

: 90-02-8
salicylaldehyde

: 103074-40-4
2-{2-[3-(4-o-Tolyl-piperazin-1-yl)-propoxy]-phenyl}-thiazolidine-3-carbothioic acid methylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / K₂CO₃ / dimethylformamide / 68 h / Ambient temperature

2: 53 percent

3: 91 percent / K₂CO₃/NaI / dimethylformamide / 20 h / 80 °C

With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.35.2394