2-[5-(2-phenylethynyl)-4-methyl-3-(3,4,5-trimethoxybenzoyl)-thiophen-2-yl]-isoindole-1,3-dione

Base Information

Chemical Name:2-[5-(2-phenylethynyl)-4-methyl-3-(3,4,5-trimethoxybenzoyl)-thiophen-2-yl]-isoindole-1,3-dione
CAS No.:1309872-47-6
Molecular Formula:C₃₁H₂₃NO₆S
Molecular Weight:537.593
Hs Code.:

Synonyms:2-[5-(2-phenylethynyl)-4-methyl-3-(3,4,5-trimethoxybenzoyl)-thiophen-2-yl]-isoindole-1,3-dione

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Chemical Property of 2-[5-(2-phenylethynyl)-4-methyl-3-(3,4,5-trimethoxybenzoyl)-thiophen-2-yl]-isoindole-1,3-dione

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Technology Process of 2-[5-(2-phenylethynyl)-4-methyl-3-(3,4,5-trimethoxybenzoyl)-thiophen-2-yl]-isoindole-1,3-dione

There total 4 articles about 2-[5-(2-phenylethynyl)-4-methyl-3-(3,4,5-trimethoxybenzoyl)-thiophen-2-yl]-isoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 901118-53-4
2-[4-methyl-5-bromo-3-(3,4,5-trimethoxybenzoyl)-2-thienyl]-1H-isoindole-1,3(2H)-dione

: 536-74-3
phenylacetylene

: 1309872-47-6
2-[5-(2-phenylethynyl)-4-methyl-3-(3,4,5-trimethoxybenzoyl)-thiophen-2-yl]-isoindole-1,3-dione

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.bmcl.2010.11.083

Reference yield:

: 901118-42-1
(2-amino-4-methylthiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone

: 1309872-47-6
2-[5-(2-phenylethynyl)-4-methyl-3-(3,4,5-trimethoxybenzoyl)-thiophen-2-yl]-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / Inert atmosphere

2: bromine; sodium acetate; acetic acid / 20 °C / Inert atmosphere

3: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; bromine; sodium acetate; acetic acid; triethylamine; In N,N-dimethyl-formamide; 3: Sonogashira cross-coupling;
DOI:10.1016/j.bmcl.2010.11.083

Reference yield:

: 901118-50-1
2-[4-methyl-3-(3,4,5-trimethoxybenzoyl)-2-thienyl]-1H-isoindole-1,3(2H)-dione

: 1309872-47-6
2-[5-(2-phenylethynyl)-4-methyl-3-(3,4,5-trimethoxybenzoyl)-thiophen-2-yl]-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: bromine; sodium acetate; acetic acid / 20 °C / Inert atmosphere

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; bromine; sodium acetate; acetic acid; triethylamine; In N,N-dimethyl-formamide; 2: Sonogashira cross-coupling;
DOI:10.1016/j.bmcl.2010.11.083