tert-butyl (3S,5R)-3-[{[2-chloro-5-(4-methoxybutyl)-1-phenyl-1H-imidazol-4-yl]carbonyl}(2-methylpropyl)amino]-5-(morpholin-4-ylcarbonyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (3S,5R)-3-[{[2-chloro-5-(4-methoxybutyl)-1-phenyl-1H-imidazol-4-yl]carbonyl}(2-methylpropyl)amino]-5-(morpholin-4-ylcarbonyl)piperidine-1-carboxylate
CAS No.:1202263-37-3
Molecular Formula:C₃₄H₅₀ClN₅O₆
Molecular Weight:660.254
Hs Code.:

tert-butyl (3S,5R)-3-[{[2-chloro-5-(4-methoxybutyl)-1-phenyl-1H-imidazol-4-yl]carbonyl}(2-methylpropyl)amino]-5-(morpholin-4-ylcarbonyl)piperidine-1-carboxylate

Synonyms:tert-butyl (3S,5R)-3-[{[2-chloro-5-(4-methoxybutyl)-1-phenyl-1H-imidazol-4-yl]carbonyl}(2-methylpropyl)amino]-5-(morpholin-4-ylcarbonyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl (3S,5R)-3-[{[2-chloro-5-(4-methoxybutyl)-1-phenyl-1H-imidazol-4-yl]carbonyl}(2-methylpropyl)amino]-5-(morpholin-4-ylcarbonyl)piperidine-1-carboxylate

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Technology Process of tert-butyl (3S,5R)-3-[{[2-chloro-5-(4-methoxybutyl)-1-phenyl-1H-imidazol-4-yl]carbonyl}(2-methylpropyl)amino]-5-(morpholin-4-ylcarbonyl)piperidine-1-carboxylate

There total 15 articles about tert-butyl (3S,5R)-3-[{[2-chloro-5-(4-methoxybutyl)-1-phenyl-1H-imidazol-4-yl]carbonyl}(2-methylpropyl)amino]-5-(morpholin-4-ylcarbonyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 2-chloro-5-(4-methoxybutyl)-1-phenyl-1H-imidazole-4-carboxylic acid

: 1145747-65-4
tert-butyl (3S,5R)-3-[(2-methylpropyl)amino]-5-(morpholin-4-ylcarbonyl)piperidine-1-carboxylate

: 1202263-37-3
tert-butyl (3S,5R)-3-[{[2-chloro-5-(4-methoxybutyl)-1-phenyl-1H-imidazol-4-yl]carbonyl}(2-methylpropyl)amino]-5-(morpholin-4-ylcarbonyl)piperidine-1-carboxylate

Guidance literature:: With N,N,N',N'-tetramethylchloroformamidinium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2018.04.051

Reference yield:

: 920297-39-8
1-(tert-butoxycarbonyl)piperidine-3,5-dicarboxylic acid

: 1202263-37-3
tert-butyl (3S,5R)-3-[{[2-chloro-5-(4-methoxybutyl)-1-phenyl-1H-imidazol-4-yl]carbonyl}(2-methylpropyl)amino]-5-(morpholin-4-ylcarbonyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: acetic anhydride / 3 h / Reflux

2: hydroquinidine (anthraquinone-1,4-diyl) diether / methanol; diethyl ether; tetrahydrofuran / 24 h / -40 °C / Inert atmosphere

3: diphenyl phosphoryl azide; triethylamine / toluene / 1 h / 100 °C

4: sodium hydroxide / methanol; water / 12 h / 20 °C / Cooling with ice

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 96 h / 20 °C

6: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol / 16 h / 20 °C

7: N-ethyl-N,N-diisopropylamine; N,N,N',N'-tetramethylchloroformamidinium hexafluorophosphate / 1,2-dichloro-ethane / 2 h / 20 °C

With diphenyl phosphoryl azide; 10 wt% Pd(OH)2 on carbon; hydrogen; acetic anhydride; benzotriazol-1-ol; N,N,N',N'-tetramethylchloroformamidinium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; hydroquinidine (anthraquinone-1,4-diyl) diether; In tetrahydrofuran; methanol; diethyl ether; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2018.04.051

Reference yield:

: 914260-44-9
2,4-dioxo-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylic acid tert-butyl ester

: 1202263-37-3
tert-butyl (3S,5R)-3-[{[2-chloro-5-(4-methoxybutyl)-1-phenyl-1H-imidazol-4-yl]carbonyl}(2-methylpropyl)amino]-5-(morpholin-4-ylcarbonyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: quinidine / methanol; tetrahydrofuran / 7 h / -40 °C

2: diphenyl phosphoryl azide; triethylamine / toluene / 1 h / 100 °C

3: sodium hydroxide / methanol; water / 12 h / 20 °C / Cooling with ice

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 96 h / 20 °C

5: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol / 16 h / 20 °C

6: N-ethyl-N,N-diisopropylamine; N,N,N',N'-tetramethylchloroformamidinium hexafluorophosphate / 1,2-dichloro-ethane / 2 h / 20 °C

With diphenyl phosphoryl azide; 10 wt% Pd(OH)2 on carbon; hydrogen; benzotriazol-1-ol; N,N,N',N'-tetramethylchloroformamidinium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; quinidine; In tetrahydrofuran; methanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2018.04.051