4,6-DICHLORO-1-BENZOFURAN

Base Information

• Chemical Name: 4,6-DICHLORO-1-BENZOFURAN
• CAS No.: 175203-95-9
• Molecular Formula: C₈H₄Cl₂O
• Molecular Weight: 187.025
• Mol file: 175203-95-9.mol

Synonyms:4,6-Dichlorobenzofuran

Chemical Property of 4,6-DICHLORO-1-BENZOFURAN

Chemical Property:

• PSA: 13.14000
• LogP: 3.73960
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%min ^*data from raw suppliers

4,6-Dichlorobenzofuran 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,6-DICHLORO-1-BENZOFURAN

There total 2 articles about 4,6-DICHLORO-1-BENZOFURAN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2-(2-bromo-4,6-dichlorophenyl)acetaldehyde (1391575-68-0) → 4,6-dichlorobenzofuran (175203-95-9)

Guidance literature:

With potassium phosphate; copper(l) iodide; In N,N-dimethyl-formamide; at 70 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ja305660a

Reference yield:

2,4-dichloro-6-bromoaniline (697-86-9) → 4,6-dichlorobenzofuran (175203-95-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / water; acetone

1.2: 0.03 h / Sonication

2.1: copper(l) iodide; potassium phosphate / N,N-dimethyl-formamide / 2 h / 70 °C / Inert atmosphere

With hydrogenchloride; potassium phosphate; copper(l) iodide; In water; N,N-dimethyl-formamide; acetone;

DOI:10.1021/ja305660a

upstream raw materials:

2-(2-bromo-4,6-dichlorophenyl)acetaldehyde

2,4-dichloro-6-bromoaniline

Refernces

• 1、 Chernyak, Natalia,Buchwald, Stephen L.. "Erratum: Continuous-flow synthesis of monoarylated acetaldehydes using aryldiazonium salts (Journal of the American Chemical Society (2012) 134 (2466-12469))". supporting information. p. 18147 - 18147,1. Retrieved 2020/10/15.