(S)-1-(benzyloxycarbonyl)-2-methylpropyl 4'-nonylbiphenyl-4-carboxylate

Base Information

• Chemical Name: (S)-1-(benzyloxycarbonyl)-2-methylpropyl 4'-nonylbiphenyl-4-carboxylate
• CAS No.: 125150-36-9
• Molecular Formula: C₃₄H₄₂O₄
• Molecular Weight: 514.705
• Mol file: 125150-36-9.mol

Synonyms:(S)-1-(benzyloxycarbonyl)-2-methylpropyl 4'-nonylbiphenyl-4-carboxylate

Chemical Property of (S)-1-(benzyloxycarbonyl)-2-methylpropyl 4'-nonylbiphenyl-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-(benzyloxycarbonyl)-2-methylpropyl 4'-nonylbiphenyl-4-carboxylate

There total 3 articles about (S)-1-(benzyloxycarbonyl)-2-methylpropyl 4'-nonylbiphenyl-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(S)-2-hydroxy-3-methylbutyric acid benzyl ester (65138-05-8) + 4'-nonylbiphenyl-4-carboxylic acid ester (118826-99-6) → (S)-1-(benzyloxycarbonyl)-2-methylpropyl 4'-nonylbiphenyl-4-carboxylate (125150-36-9)

Guidance literature:

With 4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide; In dichloromethane; for 6h; Ambient temperature;

Reference yield:

L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) → (S)-1-(benzyloxycarbonyl)-2-methylpropyl 4'-nonylbiphenyl-4-carboxylate (125150-36-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaNO₂, 0.5 M H₂SO₄, 2.) NaOH / 1.) water, -2-0 deg C, 3 h, overnight, room temp., 2.) water, pH=4.5-5.0

2: 96 percent / dimethylformamide / 24 h / Ambient temperature

3: 91 percent / DCC, 4-(N-pyrrolidino)pyridine / CH₂Cl₂ / 6 h / Ambient temperature

With sodium hydroxide; sulfuric acid; 4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide; sodium nitrite; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

(S)-(-)-sodium 2-hydroxy-3-methylbutanoate (54641-19-9) → (S)-1-(benzyloxycarbonyl)-2-methylpropyl 4'-nonylbiphenyl-4-carboxylate (125150-36-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / dimethylformamide / 24 h / Ambient temperature

2: 91 percent / DCC, 4-(N-pyrrolidino)pyridine / CH₂Cl₂ / 6 h / Ambient temperature

With 4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

(S)-2-hydroxy-3-methylbutyric acid benzyl ester

4'-nonylbiphenyl-4-carboxylic acid ester

L-valine

(S)-(-)-sodium 2-hydroxy-3-methylbutanoate

Downstream raw materials:

(S)-1-carbamoyl-2-methylpropyl 4'-nonylbiphenyl-4-carboxylate