Butyl-[2-(3,4-dimethoxy-phenyl)-ethyl]-{3-[4-(2-isopropyl-indolizine-1-sulfonyl)-phenoxy]-propyl}-amine

Base Information

• Chemical Name: Butyl-[2-(3,4-dimethoxy-phenyl)-ethyl]-{3-[4-(2-isopropyl-indolizine-1-sulfonyl)-phenoxy]-propyl}-amine
• CAS No.: 114432-97-2
• Molecular Formula: C₃₄H₄₄N₂O₅S
• Molecular Weight: 592.8
• Mol file: 114432-97-2.mol

Synonyms:Butyl-[2-(3,4-dimethoxy-phenyl)-ethyl]-{3-[4-(2-isopropyl-indolizine-1-sulfonyl)-phenoxy]-propyl}-amine

Chemical Property of Butyl-[2-(3,4-dimethoxy-phenyl)-ethyl]-{3-[4-(2-isopropyl-indolizine-1-sulfonyl)-phenoxy]-propyl}-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Butyl-[2-(3,4-dimethoxy-phenyl)-ethyl]-{3-[4-(2-isopropyl-indolizine-1-sulfonyl)-phenoxy]-propyl}-amine

There total 6 articles about Butyl-[2-(3,4-dimethoxy-phenyl)-ethyl]-{3-[4-(2-isopropyl-indolizine-1-sulfonyl)-phenoxy]-propyl}-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloromethylpyridine (4377-33-7) → Butyl-[2-(3,4-dimethoxy-phenyl)-ethyl]-{3-[4-(2-isopropyl-indolizine-1-sulfonyl)-phenoxy]-propyl}-amine (114432-97-2)

Guidance literature:

Multi-step reaction with 5 steps

1: AcONa / butan-1-ol

2: 70 percent / K₂CO₃ / butan-2-one / 2 h / Heating

3: 90 percent / aq. NaOH / ethanol / 24 h / Heating

4: 85 percent / K₂CO₃ / butan-2-one / 24 h / Heating

5: Et₃N / toluene / 24 h / Heating

With sodium hydroxide; sodium acetate; potassium carbonate; triethylamine; In ethanol; toluene; butanone; butan-1-ol;

DOI:10.1021/jm00084a002

Reference yield:

2-isopropyl-1-<(4-hydroxyphenyl)sulfonyl>indolizine (114432-21-2) → Butyl-[2-(3,4-dimethoxy-phenyl)-ethyl]-{3-[4-(2-isopropyl-indolizine-1-sulfonyl)-phenoxy]-propyl}-amine (114432-97-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / K₂CO₃ / butan-2-one / 24 h / Heating

2: Et₃N / toluene / 24 h / Heating

With potassium carbonate; triethylamine; In toluene; butanone;

DOI:10.1021/jm00084a002

Reference yield:

5-tosyloxyphenyl 2-methylpyridyl sulfone (133804-17-8) → Butyl-[2-(3,4-dimethoxy-phenyl)-ethyl]-{3-[4-(2-isopropyl-indolizine-1-sulfonyl)-phenoxy]-propyl}-amine (114432-97-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 70 percent / K₂CO₃ / butan-2-one / 2 h / Heating

2: 90 percent / aq. NaOH / ethanol / 24 h / Heating

3: 85 percent / K₂CO₃ / butan-2-one / 24 h / Heating

4: Et₃N / toluene / 24 h / Heating

With sodium hydroxide; potassium carbonate; triethylamine; In ethanol; toluene; butanone;

DOI:10.1021/jm00084a002

upstream raw materials:

N-<2-(3,4-dimethoxyphenyl)ethyl>butanamide

2-Isopropyl-1-[4-(3-bromopropyloxy)benzenesulphonyl]indolizine

2-chloromethylpyridine

2-isopropyl-1-<(4-hydroxyphenyl)sulfonyl>indolizine