3-Amino-4-(4-chlorophenyl)sulfonylthiophene-2-carboxylic acid

Base Information

Chemical Name:3-Amino-4-(4-chlorophenyl)sulfonylthiophene-2-carboxylic acid
CAS No.:175201-47-5
Molecular Formula:C11H8 Cl N O4 S2
Molecular Weight:317.77
Hs Code.:2934999090
DSSTox Substance ID:DTXSID20441219
Wikidata:Q82257887
Mol file:175201-47-5.mol

Synonyms:175201-47-5;3-amino-4-(4-chlorophenyl)sulfonylthiophene-2-carboxylic acid;3-Amino-4-(4-chlorobenzenesulphonyl)thiophene-2-carboxylic acid;3-Amino-4-[(4-chlorophenyl)sulphonyl]thiophene-2-carboxylic acid;2-Thiophenecarboxylic acid, 3-amino-4-[(4-chlorophenyl)sulfonyl]-;SCHEMBL7806620;DTXSID20441219;MNBSBKFCJJWHEB-UHFFFAOYSA-N;MFCD00173768;3-Amino-4-(4-chlorobenzene-1-sulfonyl)thiophene-2-carboxylic acid

Suppliers and Price of 3-Amino-4-(4-chlorophenyl)sulfonylthiophene-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
3-AMINO-4-[(4-CHLOROPHENYL)SULPHONYL]THIOPHENE-2-CARBOXYLIC ACID 95.00%
10G
$ 2286.04

Total 2 raw suppliers

Chemical Property of 3-Amino-4-(4-chlorophenyl)sulfonylthiophene-2-carboxylic acid

Chemical Property:

PSA：134.08000
LogP:4.17670
XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:316.9583278
Heavy Atom Count:19
Complexity:442

Purity/Quality:

97% ^*data from raw suppliers

3-AMINO-4-[(4-CHLOROPHENYL)SULPHONYL]THIOPHENE-2-CARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1S(=O)(=O)C2=CSC(=C2N)C(=O)O)Cl

Technology Process of 3-Amino-4-(4-chlorophenyl)sulfonylthiophene-2-carboxylic acid

There total 2 articles about 3-Amino-4-(4-chlorophenyl)sulfonylthiophene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 175137-53-8
methyl 3-amino-4-(4-chlorophenylsulfony)l-2-thiophenecarboxylate

: 175201-47-5
3-amino-4-(4-chlorophenylsulfonyl)-2-thiophenecarboxylic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; at 100 ℃;
DOI:10.1002/jhet.5570360314

Reference yield:

: 32083-27-5
2-p-Chlorphenylsulfonyl-3-ethoxyacrylnitril

: 175201-47-5
3-amino-4-(4-chlorophenylsulfonyl)-2-thiophenecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / Et₃N / tetrahydrofuran / 2 h / 75 - 80 °C

2: 97 percent / 5N aq. NaOH / dioxane / 100 °C

With sodium hydroxide; triethylamine; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1002/jhet.5570360314

Reference yield:

: 127000-91-3
(2R,3R)-3-Amino-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

: 175201-47-5
3-amino-4-(4-chlorophenylsulfonyl)-2-thiophenecarboxylic acid

: 3-Amino-4-(4-chloro-benzenesulfonyl)-thiophene-2-carboxylic acid [(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-amide

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; for 18h; Ambient temperature;
DOI:10.1021/jm970726e