5-(6-hyroxy-7-(3-methylbut-2-enyl)benzofuran-2-yl)benzene-1,3-diol,

Base Information

• Chemical Name: 5-(6-hyroxy-7-(3-methylbut-2-enyl)benzofuran-2-yl)benzene-1,3-diol,
• CAS No.: 1146113-26-9
• Molecular Formula: C₁₉H₁₈O₄
• Molecular Weight: 310.35
• Mol file: 1146113-26-9.mol

Synonyms:5-(6-hyroxy-7-(3-methylbut-2-enyl)benzofuran-2-yl)benzene-1,3-diol,

Chemical Property of 5-(6-hyroxy-7-(3-methylbut-2-enyl)benzofuran-2-yl)benzene-1,3-diol,

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(6-hyroxy-7-(3-methylbut-2-enyl)benzofuran-2-yl)benzene-1,3-diol,

There total 11 articles about 5-(6-hyroxy-7-(3-methylbut-2-enyl)benzofuran-2-yl)benzene-1,3-diol, which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

6-hydroxy-2-(3,5-dimethoxyphenyl)-7-(3-methylbut-2-enyl)benzofuran → 5-(6-hyroxy-7-(3-methylbut-2-enyl)benzofuran-2-yl)benzene-1,3-diol, (1146113-26-9)

Guidance literature:

With boron tribromide; In dichloromethane; at -78 - 0 ℃; for 20h; Inert atmosphere;

DOI:10.5012/bkcs.2014.35.12.3453

Reference yield: 15.0%

6-methoxy-2-(3,5-dimethoxyphenyl)-7-(3-methylbut-2-enyl)benzofuran → 5-(6-hyroxy-7-(3-methylbut-2-enyl)benzofuran-2-yl)benzene-1,3-diol, (1146113-26-9) + 5-(6-methoxy-7-(3-methylbut-2-enyl)benzofuran-2-yl)benzene-1,3-diol (1336907-14-2)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; sodium hydroxide; 1-dodecylthiol; at 130 ℃; for 24h; Inert atmosphere;

DOI:10.3390/molecules26051327

Reference yield:

4-Acetoxy-2-hydroxybromobenzene (148730-82-9) → 5-(6-hyroxy-7-(3-methylbut-2-enyl)benzofuran-2-yl)benzene-1,3-diol, (1146113-26-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 0.5 h / 0 °C

1.2: 0 °C

2.1: Pd/CaCO₃; quinoline; hydrogen / ethanol / 4 h / 20 °C

3.1: diisopropylamine; palladium diacetate; copper(l) iodide; tri tert-butylphosphoniumtetrafluoroborate / 72 h / 40 °C / Inert atmosphere

4.1: water; ethanol / 9 h / 100 °C / Sealed tube

5.1: potassium hydroxide; water / methanol / 5 h / Inert atmosphere; Reflux

6.1: boron tribromide / dichloromethane / 20 h / -78 - 0 °C / Inert atmosphere

With quinoline; copper(l) iodide; ethanol; Pd/CaCO₃; water; hydrogen; palladium diacetate; boron tribromide; 1,8-diazabicyclo[5.4.0]undec-7-ene; diisopropylamine; potassium hydroxide; tri tert-butylphosphoniumtetrafluoroborate; In methanol; ethanol; dichloromethane; 3.1: |Sonogashira Cross-Coupling;

DOI:10.5012/bkcs.2014.35.12.3453

upstream raw materials:

4-Bromoresorcinol

4-Acetoxy-2-hydroxybromobenzene

2-iodo-5-methoxyphenol

1-Ethynyl-3,5-dimethoxy-benzene