N-tert-butyl 2-(3-bromo-2-oxo-5-(3-chlorophenyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)ethanoic acid amide

Base Information

Chemical Name:N-tert-butyl 2-(3-bromo-2-oxo-5-(3-chlorophenyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)ethanoic acid amide
CAS No.:152607-64-2
Molecular Formula:C₂₂H₂₄BrClN₂O₂
Molecular Weight:463.802
Hs Code.:

Synonyms:N-tert-butyl 2-(3-bromo-2-oxo-5-(3-chlorophenyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)ethanoic acid amide

Suppliers and Price of N-tert-butyl 2-(3-bromo-2-oxo-5-(3-chlorophenyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)ethanoic acid amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-tert-butyl 2-(3-bromo-2-oxo-5-(3-chlorophenyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)ethanoic acid amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-tert-butyl 2-(3-bromo-2-oxo-5-(3-chlorophenyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)ethanoic acid amide

There total 10 articles about N-tert-butyl 2-(3-bromo-2-oxo-5-(3-chlorophenyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)ethanoic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 152607-64-2
N-tert-butyl 2-(3-bromo-2-oxo-5-(3-chlorophenyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)ethanoic acid amide

Guidance literature:

Reference yield:

: 1016-78-0
3-chlorobenzophenone

: 152607-64-2
N-tert-butyl 2-(3-bromo-2-oxo-5-(3-chlorophenyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)ethanoic acid amide

Guidance literature:: Multi-step reaction with 8 steps

1: t-BuOK / 2-methyl-propan-2-ol / 14 h / Heating

2: acetic acid, 48percent aq. HBr / 14 h / Heating

3: H₂ / 10percent Pd/C / ethyl acetate / 2 h / 1551.4 Torr

4: SOCl₂ / toluene / 1 h / Heating

5: 1.) AlCl₃, 2.) hydroxylamine hydrochloride, Et₃N / 1.) CS₂, 16 h, 2.) MeOH, RT, 3 d

6: 51 percent / polyphosphoric acid / 0.42 h / 130 °C

7: 1.) PCl₅, pyridine, 2.) Br₂ / 1.) CH₂Cl₂, 15 min, 2.) CH₂Cl₂, from -45 deg C to RT

8: 1.) LiN(SiMe₃)2 / 1.) THF, 5 min, 2.) THF, DMSO, RT, 1 h

With pyridine; aluminium trichloride; thionyl chloride; PPA; phosphorus pentachloride; hydroxylamine hydrochloride; potassium tert-butylate; hydrogen bromide; hydrogen; bromine; acetic acid; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In ethyl acetate; toluene; tert-butyl alcohol;
DOI:10.1021/jm00048a015

Reference yield:

: 4-phenyl-4-(3-chlorophenyl)but-3-enoic acid

: 152607-64-2
N-tert-butyl 2-(3-bromo-2-oxo-5-(3-chlorophenyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)ethanoic acid amide

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / 10percent Pd/C / ethyl acetate / 2 h / 1551.4 Torr

2: SOCl₂ / toluene / 1 h / Heating

3: 1.) AlCl₃, 2.) hydroxylamine hydrochloride, Et₃N / 1.) CS₂, 16 h, 2.) MeOH, RT, 3 d

4: 51 percent / polyphosphoric acid / 0.42 h / 130 °C

5: 1.) PCl₅, pyridine, 2.) Br₂ / 1.) CH₂Cl₂, 15 min, 2.) CH₂Cl₂, from -45 deg C to RT

6: 1.) LiN(SiMe₃)2 / 1.) THF, 5 min, 2.) THF, DMSO, RT, 1 h

With pyridine; aluminium trichloride; thionyl chloride; PPA; phosphorus pentachloride; hydroxylamine hydrochloride; hydrogen; bromine; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In ethyl acetate; toluene;
DOI:10.1021/jm00048a015