3'-(4-chloro-2,5-dimethyl-benzenesulfonylamino)-3,5-dimethyl-biphenyl-4-carboxylic acid chloride

Base Information

• Chemical Name: 3'-(4-chloro-2,5-dimethyl-benzenesulfonylamino)-3,5-dimethyl-biphenyl-4-carboxylic acid chloride
• CAS No.: 1011479-55-2
• Molecular Formula: C₂₃H₂₁Cl₂NO₃S
• Molecular Weight: 462.397

Synonyms:3'-(4-chloro-2,5-dimethyl-benzenesulfonylamino)-3,5-dimethyl-biphenyl-4-carboxylic acid chloride

Chemical Property of 3'-(4-chloro-2,5-dimethyl-benzenesulfonylamino)-3,5-dimethyl-biphenyl-4-carboxylic acid chloride

Chemical Property:

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Technology Process of 3'-(4-chloro-2,5-dimethyl-benzenesulfonylamino)-3,5-dimethyl-biphenyl-4-carboxylic acid chloride

There total 1 articles about 3'-(4-chloro-2,5-dimethyl-benzenesulfonylamino)-3,5-dimethyl-biphenyl-4-carboxylic acid chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3'-(4-chloro-2,5-dimethyl-benzenesulfonylamino)-3,5-dimethyl-biphenyl-4-carboxylic acid (1011479-54-1) → 3'-(4-chloro-2,5-dimethyl-benzenesulfonylamino)-3,5-dimethyl-biphenyl-4-carboxylic acid chloride (1011479-55-2)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; for 0.5 - 1h; Heating / reflux;

Reference yield: 80.0%

3'-(4-chloro-2,5-dimethyl-benzenesulfonylamino)-3,5-dimethyl-biphenyl-4-carboxylic acid chloride (1011479-55-2) + C11H22N2O4 (201867-49-4) → (S)-2-{[3'-(4-chloro-2,5-dimethylphenylsulfonylamino)-3,5-dimethylbiphenyl-4-carbonyl]methylamino}-4-tert-butoxycarbonylaminobutyric acid methyl ester

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jm3009508

Reference yield:

3'-(4-chloro-2,5-dimethyl-benzenesulfonylamino)-3,5-dimethyl-biphenyl-4-carboxylic acid chloride (1011479-55-2) + R-(-)-serine methyl ester hydrochloride (5874-57-7) → (R)-2-{[3'-(4-chloro-2,5-dimethyl-benzenesulfonylamino)-3,5-dimethyl-biphenyl-4-carbonyl]-amino}-3-hydroxy-propionic acid methyl ester

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 16h;

upstream raw materials:

3'-(4-chloro-2,5-dimethyl-benzenesulfonylamino)-3,5-dimethyl-biphenyl-4-carboxylic acid

Downstream raw materials:

(S)-2-{[3'-(4-chloro-2,5-dimethylphenylsulfonylamino)-3,5-dimethyl-biphenyl-4-carbonyl]-amino}-4-tertbutoxycarbonylamino-butyric acid

C₂₇H₂₈ClN₃O₄S

(S)-2-{[3'-(4-chloro-2,5-dimethylphenylsulfonylamino)-3,5-dimethyl-biphenyl-4-carbonyl]-amino}-4-tertbutoxycarbonylamino-butyric acid methyl ester

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