4-(N-(4-cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-((perfluorophenyl)methyl)phenylsulfonamido)acetamido)-2-hydroxybenzoic acid

Base Information

Chemical Name:4-(N-(4-cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-((perfluorophenyl)methyl)phenylsulfonamido)acetamido)-2-hydroxybenzoic acid
CAS No.:1455006-68-4
Molecular Formula:C₃₅H₂₆F₁₀N₂O₆S
Molecular Weight:792.651
Hs Code.:

Synonyms:4-(N-(4-cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-((perfluorophenyl)methyl)phenylsulfonamido)acetamido)-2-hydroxybenzoic acid

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Chemical Property of 4-(N-(4-cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-((perfluorophenyl)methyl)phenylsulfonamido)acetamido)-2-hydroxybenzoic acid

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Technology Process of 4-(N-(4-cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-((perfluorophenyl)methyl)phenylsulfonamido)acetamido)-2-hydroxybenzoic acid

There total 7 articles about 4-(N-(4-cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-((perfluorophenyl)methyl)phenylsulfonamido)acetamido)-2-hydroxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1455006-38-8
benzyl 2-(benzyloxy)-4-(N-(4-cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-(2,3,5,6,-tetrafluorobenzyl)phenylsulfonamido)acetamido)benzoate

: 1455006-68-4
4-(N-(4-cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-((perfluorophenyl)methyl)phenylsulfonamido)acetamido)-2-hydroxybenzoic acid

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; at 20 ℃; for 6h; Inert atmosphere;
DOI:10.1021/jm3017255

Reference yield:

: 1241832-99-4
benzyl 4-amino-2-(benzyloxy)benzoate

: 1455006-68-4
4-(N-(4-cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-((perfluorophenyl)methyl)phenylsulfonamido)acetamido)-2-hydroxybenzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid / methanol / 3 h / 45 °C / Molecular sieve; Inert atmosphere

1.2: 45 °C / Inert atmosphere

2.1: dichlorotriphenylphosphorane / chloroform-d1 / 0.25 h / 20 °C / Inert atmosphere

2.2: 0.5 h / 110 °C / Inert atmosphere; Microwave irradiation

3.1: piperidine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4.1: potassium carbonate / acetonitrile / 0 - 20 °C / Inert atmosphere; Molecular sieve

5.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

6.1: palladium 10% on activated carbon; hydrogen / methanol; tetrahydrofuran / 6 h / 20 °C / Inert atmosphere

With piperidine; palladium 10% on activated carbon; hydrogen; potassium carbonate; caesium carbonate; acetic acid; dichlorotriphenylphosphorane; In tetrahydrofuran; methanol; chloroform-d1; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm3017255

Reference yield:

: 1241833-16-8
benzyl 2-(benzyloxy)-4-((4-cyclohexylbenzyl)amino)benzoate

: 1455006-68-4
4-(N-(4-cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-((perfluorophenyl)methyl)phenylsulfonamido)acetamido)-2-hydroxybenzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: dichlorotriphenylphosphorane / chloroform-d1 / 0.25 h / 20 °C / Inert atmosphere

1.2: 0.5 h / 110 °C / Inert atmosphere; Microwave irradiation

2.1: piperidine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3.1: potassium carbonate / acetonitrile / 0 - 20 °C / Inert atmosphere; Molecular sieve

4.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

5.1: palladium 10% on activated carbon; hydrogen / methanol; tetrahydrofuran / 6 h / 20 °C / Inert atmosphere

With piperidine; palladium 10% on activated carbon; hydrogen; potassium carbonate; caesium carbonate; dichlorotriphenylphosphorane; In tetrahydrofuran; methanol; chloroform-d1; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm3017255