(5R)-5-methyl-4-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]-1-[4-methyl-5-(trifluoromethyl)pyrimidin-2-yl]-1,4-diazepane

Base Information

Chemical Name:(5R)-5-methyl-4-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]-1-[4-methyl-5-(trifluoromethyl)pyrimidin-2-yl]-1,4-diazepane
CAS No.:1030377-64-0
Molecular Formula:C₂₂H₂₄F₃N₇O
Molecular Weight:459.474
Hs Code.:

Synonyms:(5R)-5-methyl-4-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]-1-[4-methyl-5-(trifluoromethyl)pyrimidin-2-yl]-1,4-diazepane

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Chemical Property of (5R)-5-methyl-4-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]-1-[4-methyl-5-(trifluoromethyl)pyrimidin-2-yl]-1,4-diazepane

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Technology Process of (5R)-5-methyl-4-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]-1-[4-methyl-5-(trifluoromethyl)pyrimidin-2-yl]-1,4-diazepane

There total 1 articles about (5R)-5-methyl-4-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]-1-[4-methyl-5-(trifluoromethyl)pyrimidin-2-yl]-1,4-diazepane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1030377-63-9
(5R)-1-[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]-5-methyl-4-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepane

: 594-27-4
tetramethylstannane

: 1030377-64-0
(5R)-5-methyl-4-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]-1-[4-methyl-5-(trifluoromethyl)pyrimidin-2-yl]-1,4-diazepane

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium chloride; In N,N-dimethyl-formamide; at 110 ℃; for 14h;
DOI:10.1016/j.bmcl.2014.12.081