Technology Process of 1-bromo-2-(di-p-tert-butylphenyl)phosphinobenzene
There total 3 articles about 1-bromo-2-(di-p-tert-butylphenyl)phosphinobenzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
bis(4-tert-butylpheny)chlorophosphine;
With
lithium aluminium tetrahydride;
In
diethyl ether;
at 0 - 10 ℃;
for 2h;
With
hydrogenchloride;
In
diethyl ether; water;
1-Bromo-2-iodobenzene;
With
palladium diacetate; triethylamine;
In
acetonitrile;
at 100 ℃;
for 12h;
Inert atmosphere;
DOI:10.1021/ol303567t
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: pyridine / diethyl ether / 4 h / -78 °C / Reflux
1.2: 3 h / 20 °C
2.1: phosphorus trichloride / benzene / 0.5 h / 0 - 10 °C
3.1: lithium aluminium tetrahydride / diethyl ether / 2 h / 0 - 10 °C
3.3: 12 h / 100 °C / Inert atmosphere
With
pyridine; lithium aluminium tetrahydride; phosphorus trichloride;
In
diethyl ether; benzene;
DOI:10.1021/ol303567t
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: phosphorus trichloride / benzene / 0.5 h / 0 - 10 °C
2.1: lithium aluminium tetrahydride / diethyl ether / 2 h / 0 - 10 °C
2.3: 12 h / 100 °C / Inert atmosphere
With
lithium aluminium tetrahydride; phosphorus trichloride;
In
diethyl ether; benzene;
DOI:10.1021/ol303567t
