Technology Process of (3aS,8aR)-3a-allyl-1,8-dimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl phenylcarbamate
There total 11 articles about (3aS,8aR)-3a-allyl-1,8-dimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl phenylcarbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C15H20N2O;
With
sodium;
In
diethyl ether;
at 20 ℃;
for 0.25h;
Inert atmosphere;
phenyl isocyanate;
In
diethyl ether;
for 0.5h;
Inert atmosphere;
DOI:10.1016/j.bmc.2012.06.048
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / Inert atmosphere; Reflux
2.1: boron tribromide / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere
2.2: 0.5 h
3.1: sodium / diethyl ether / 0.25 h / 20 °C / Inert atmosphere
3.2: 0.5 h / Inert atmosphere
With
lithium aluminium tetrahydride; sodium; boron tribromide;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/j.bmc.2012.06.048
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere
1.2: 0.5 h / Inert atmosphere
2.1: lithium hydroxide monohydrate; dihydrogen peroxide / tetrahydrofuran; water / 72 h / 20 °C
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
4.1: tetrahydrofuran
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / Inert atmosphere; Reflux
6.1: boron tribromide / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere
6.2: 0.5 h
7.1: sodium / diethyl ether / 0.25 h / 20 °C / Inert atmosphere
7.2: 0.5 h / Inert atmosphere
With
lithium aluminium tetrahydride; lithium hydroxide monohydrate; dihydrogen peroxide; sodium; boron tribromide; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1016/j.bmc.2012.06.048
