5-{6-[tert-butoxycarbonyl-(3-methoxy-phenyl)-amino]-pyrazin-2-yl}-nicotinic acid ethyl ester

Base Information

Chemical Name:5-{6-[tert-butoxycarbonyl-(3-methoxy-phenyl)-amino]-pyrazin-2-yl}-nicotinic acid ethyl ester
CAS No.:405940-20-7
Molecular Formula:C₂₄H₂₆N₄O₅
Molecular Weight:450.494
Hs Code.:

5-{6-[<i>tert</i>-butoxycarbonyl-(3-methoxy-phenyl)-amino]-pyrazin-2-yl}-nicotinic acid ethyl ester

Synonyms:5-{6-[tert-butoxycarbonyl-(3-methoxy-phenyl)-amino]-pyrazin-2-yl}-nicotinic acid ethyl ester

Suppliers and Price of 5-{6-[tert-butoxycarbonyl-(3-methoxy-phenyl)-amino]-pyrazin-2-yl}-nicotinic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-{6-[tert-butoxycarbonyl-(3-methoxy-phenyl)-amino]-pyrazin-2-yl}-nicotinic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-{6-[tert-butoxycarbonyl-(3-methoxy-phenyl)-amino]-pyrazin-2-yl}-nicotinic acid ethyl ester

There total 3 articles about 5-{6-[tert-butoxycarbonyl-(3-methoxy-phenyl)-amino]-pyrazin-2-yl}-nicotinic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20986-40-7
ethyl 5-bromo-3-pyridinecarboxylate

: 405940-20-7
5-{6-[tert-butoxycarbonyl-(3-methoxy-phenyl)-amino]-pyrazin-2-yl}-nicotinic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: bis(tributyltin); tri-o-tolylphosphine; triethylamine / palladium acetate / acetonitrile / 22 h / 95 - 100 °C

1.2: 3.56 g / dichloro-bis(triphenylphosphine)palladium; LiCl / toluene / 23 h / 100 °C

2.1: 65 percent / tris(dibenzylideneacetone)dipalladium⁽⁰⁾*CHCl₃; 1,1'-bis(diphenylphosphino)ferrocene; Cs₂CO₃ / dioxane / 46 h / 110 °C

3.1: (dimethylamino)pyridine / CH₂Cl₂ / 4 h / 20 °C

With dmap; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 1,1'-bis-(diphenylphosphino)ferrocene; bis(tri-n-butyltin); caesium carbonate; triethylamine; tris-(o-tolyl)phosphine; palladium diacetate; In 1,4-dioxane; dichloromethane; acetonitrile; 1.2: Stille coupling;
DOI:10.1021/jm058205b

Reference yield:

: 405940-19-4
5-[6-(3-methoxyphenylamino)pyrazin-2-yl]nicotinic acid ethyl ester

: 24424-99-5
di-tert-butyl dicarbonate

: 405940-20-7
5-{6-[tert-butoxycarbonyl-(3-methoxy-phenyl)-amino]-pyrazin-2-yl}-nicotinic acid ethyl ester

Guidance literature:: With dmap; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1021/jm058205b

Reference yield:

: 405938-99-0
5-(6-chloropyrazine-2-yl)nicotinic acid ethyl ester

: 405940-20-7
5-{6-[tert-butoxycarbonyl-(3-methoxy-phenyl)-amino]-pyrazin-2-yl}-nicotinic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / tris(dibenzylideneacetone)dipalladium⁽⁰⁾*CHCl₃; 1,1'-bis(diphenylphosphino)ferrocene; Cs₂CO₃ / dioxane / 46 h / 110 °C

2: (dimethylamino)pyridine / CH₂Cl₂ / 4 h / 20 °C

With dmap; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 1,1'-bis-(diphenylphosphino)ferrocene; caesium carbonate; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm058205b