2-(4-(aminomethyl)benzonitrile)-3-(4-chlorophenyl)-3-hydroxyisoindolin-1-one

Base Information

• Chemical Name: 2-(4-(aminomethyl)benzonitrile)-3-(4-chlorophenyl)-3-hydroxyisoindolin-1-one
• CAS No.: 1202803-36-8
• Molecular Formula: C₂₂H₁₅ClN₂O₂
• Molecular Weight: 374.826
• Mol file: 1202803-36-8.mol

Synonyms:2-(4-(aminomethyl)benzonitrile)-3-(4-chlorophenyl)-3-hydroxyisoindolin-1-one

Chemical Property of 2-(4-(aminomethyl)benzonitrile)-3-(4-chlorophenyl)-3-hydroxyisoindolin-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-(aminomethyl)benzonitrile)-3-(4-chlorophenyl)-3-hydroxyisoindolin-1-one

There total 2 articles about 2-(4-(aminomethyl)benzonitrile)-3-(4-chlorophenyl)-3-hydroxyisoindolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

4'-chloro-o-benzoylbenzoic acid chloride (55275-44-0) + 4-aminobenzyl cyanide (10406-25-4) → 2-(4-(aminomethyl)benzonitrile)-3-(4-chlorophenyl)-3-hydroxyisoindolin-1-one (1202803-36-8)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 4h; Inert atmosphere;

Reference yield:

2-(4-chlorobenzoyl)benzoic acid (85-56-3) → 2-(4-(aminomethyl)benzonitrile)-3-(4-chlorophenyl)-3-hydroxyisoindolin-1-one (1202803-36-8)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride; N,N-dimethyl-formamide / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere

With thionyl chloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran;

DOI:10.1021/jm1011929

Reference yield:

2-(4-(aminomethyl)benzonitrile)-3-(4-chlorophenyl)-3-hydroxyisoindolin-1-one (1202803-36-8) → C22H14Cl2N2O (1202804-30-5)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 20 ℃; for 4h;

DOI:10.1021/jm1011929

upstream raw materials:

4'-chloro-o-benzoylbenzoic acid chloride

4-aminobenzyl cyanide

2-(4-chlorobenzoyl)benzoic acid

Downstream raw materials:

C₂₂H₁₄Cl₂N₂O

4-[1-(4-chlorophenyl)-1-(4-hydroxybutoxy)-3-oxo-1,3-dihydroisoindol-2-ylmethyl]benzonitrile

4-((1-(4-chlorophenyl)-1-((1-(hydroxymethyl)cyclopropyl)methoxy)-3-oxoisoindolin-2-yl)methyl)benzonitrile