4-chloro-2-(o-fluoro-α-hydroxybenzyl)-N-<2-(diethylamino)ethyl>-N^α-(phthalylglycyl)glycinanilide

Base Information

• Chemical Name: 4-chloro-2-(o-fluoro-α-hydroxybenzyl)-N-<2-(diethylamino)ethyl>-N^α-(phthalylglycyl)glycinanilide
• CAS No.: 59180-35-7
• Molecular Formula: C₃₁H₃₂ClFN₄O₅
• Molecular Weight: 595.07

Synonyms:4-chloro-2-(o-fluoro-α-hydroxybenzyl)-N-<2-(diethylamino)ethyl>-N^α-(phthalylglycyl)glycinanilide

Chemical Property of 4-chloro-2-(o-fluoro-α-hydroxybenzyl)-N-<2-(diethylamino)ethyl>-N^α-(phthalylglycyl)glycinanilide

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Technology Process of 4-chloro-2-(o-fluoro-α-hydroxybenzyl)-N-<2-(diethylamino)ethyl>-N^α-(phthalylglycyl)glycinanilide

There total 1 articles about 4-chloro-2-(o-fluoro-α-hydroxybenzyl)-N-<2-(diethylamino)ethyl>-N^α-(phthalylglycyl)glycinanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.8%

4'-chloro-N-<2-(diethylamino)ethyl>-2'-(o-fluoro-α-hydroxybenzyl)-2-aminoacetanilide (32566-14-6) + phthalylglycyl chloride → 4-chloro-2-(o-fluoro-α-hydroxybenzyl)-N-<2-(diethylamino)ethyl>-Nα-(phthalylglycyl)glycinanilide (59180-35-7)

Guidance literature:

In tetrahydrofuran; for 3h;

DOI:10.1021/jm00181a013

Reference yield: 75.9%

4-chloro-2-(o-fluoro-α-hydroxybenzyl)-N-<2-(diethylamino)ethyl>-Nα-(phthalylglycyl)glycinanilide (59180-35-7) → N-{[[4-Chloro-2-(2-fluoro-benzoyl)-phenyl]-(2-diethylamino-ethyl)-carbamoyl]-methyl}-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetamide (59180-38-0)

Guidance literature:

With jones reagent; In acetone;

DOI:10.1021/jm00181a013

Reference yield:

4-chloro-2-(o-fluoro-α-hydroxybenzyl)-N-<2-(diethylamino)ethyl>-Nα-(phthalylglycyl)glycinanilide (59180-35-7) → 2-Amino-N-{[[4-chloro-2-(2-fluoro-benzoyl)-phenyl]-(2-diethylamino-ethyl)-carbamoyl]-methyl}-acetamide (59180-39-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 75.9 percent / Jones reagent / acetone

2: 62.1 percent / NH₂NH₂*H₂O / ethanol / Heating

With jones reagent; hydrazine hydrate; In ethanol; acetone;

DOI:10.1021/jm00181a013

upstream raw materials:

4'-chloro-N-<2-(diethylamino)ethyl>-2'-(o-fluoro-α-hydroxybenzyl)-2-aminoacetanilide

Downstream raw materials:

N-{[[4-Chloro-2-(2-fluoro-benzoyl)-phenyl]-(2-diethylamino-ethyl)-carbamoyl]-methyl}-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetamide

2-Amino-N-{[[4-chloro-2-(2-fluoro-benzoyl)-phenyl]-(2-diethylamino-ethyl)-carbamoyl]-methyl}-acetamide

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