4,6-dichloro-5-((2-(4-(trifluoromethyl)phenyl)hydrazono)methyl)pyrimidine

Base Information

• Chemical Name: 4,6-dichloro-5-((2-(4-(trifluoromethyl)phenyl)hydrazono)methyl)pyrimidine
• CAS No.: 1429924-39-9
• Molecular Formula: C₁₂H₇Cl₂F₃N₄
• Molecular Weight: 335.116

Synonyms:4,6-dichloro-5-((2-(4-(trifluoromethyl)phenyl)hydrazono)methyl)pyrimidine

Chemical Property of 4,6-dichloro-5-((2-(4-(trifluoromethyl)phenyl)hydrazono)methyl)pyrimidine

Chemical Property:

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Technology Process of 4,6-dichloro-5-((2-(4-(trifluoromethyl)phenyl)hydrazono)methyl)pyrimidine

There total 2 articles about 4,6-dichloro-5-((2-(4-(trifluoromethyl)phenyl)hydrazono)methyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-(trifluoromethyl)phenylhydrazine hydrochloride (2923-56-0) + 2,6-dichloro-pyrimidine carbaldehyde (5305-40-8) → 4,6-dichloro-5-((2-(4-(trifluoromethyl)phenyl)hydrazono)methyl)pyrimidine (1429924-39-9)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 1h; Temperature; Reagent/catalyst; Inert atmosphere;

DOI:10.1021/ol4005382

Reference yield:

4-(trifluoromethyl)phenylhydrazine hydrochloride (2923-56-0) + 2,6-dichloro-pyrimidine carbaldehyde (5305-40-8) → 4-chloro-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidine (1269703-41-4) + 4,6-dichloro-5-((2-(4-(trifluoromethyl)phenyl)hydrazono)methyl)pyrimidine (1429924-39-9) + C12H6ClF3N4 (1429924-61-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 65 ℃; for 1h;

DOI:10.1021/ol4005382

Reference yield: 96.0%

4,6-dichloro-5-((2-(4-(trifluoromethyl)phenyl)hydrazono)methyl)pyrimidine (1429924-39-9) → 4-chloro-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidine (1269703-41-4)

Guidance literature:

In acetonitrile; at 200 ℃; for 0.333333h; Microwave irradiation;

DOI:10.1021/ol4005382

upstream raw materials:

4-(trifluoromethyl)phenylhydrazine hydrochloride

2,6-dichloro-pyrimidine carbaldehyde

Downstream raw materials:

4-chloro-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidine

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