(E)-3-((3-methyl-5-(4-(4-(thiophen-2-yl)phenethyl)-1H-1,2,3-triazol-1-yl)pent-2-en-1-yl)thio)propanoic acid

Base Information

Chemical Name:(E)-3-((3-methyl-5-(4-(4-(thiophen-2-yl)phenethyl)-1H-1,2,3-triazol-1-yl)pent-2-en-1-yl)thio)propanoic acid
CAS No.:1350561-82-8
Molecular Formula:C₂₃H₂₇N₃O₂S₂
Molecular Weight:441.618
Hs Code.:

Synonyms:(E)-3-((3-methyl-5-(4-(4-(thiophen-2-yl)phenethyl)-1H-1,2,3-triazol-1-yl)pent-2-en-1-yl)thio)propanoic acid

Suppliers and Price of (E)-3-((3-methyl-5-(4-(4-(thiophen-2-yl)phenethyl)-1H-1,2,3-triazol-1-yl)pent-2-en-1-yl)thio)propanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-3-((3-methyl-5-(4-(4-(thiophen-2-yl)phenethyl)-1H-1,2,3-triazol-1-yl)pent-2-en-1-yl)thio)propanoic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (E)-3-((3-methyl-5-(4-(4-(thiophen-2-yl)phenethyl)-1H-1,2,3-triazol-1-yl)pent-2-en-1-yl)thio)propanoic acid

There total 8 articles about (E)-3-((3-methyl-5-(4-(4-(thiophen-2-yl)phenethyl)-1H-1,2,3-triazol-1-yl)pent-2-en-1-yl)thio)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1350561-65-7
(E)-methyl 3-((3-methyl-5-(4-(4-(thiophen-2-yl)phenethyl)-1H-1,2,3-triazol-1-yl)pent-2-en-1-yl)thio)propanoate

: 1350561-82-8
(E)-3-((3-methyl-5-(4-(4-(thiophen-2-yl)phenethyl)-1H-1,2,3-triazol-1-yl)pent-2-en-1-yl)thio)propanoic acid

Guidance literature:: (E)-methyl 3-((3-methyl-5-(4-(4-(thiophen-2-yl)phenethyl)-1H-1,2,3-triazol-1-yl)pent-2-en-1-yl)thio)propanoate; In methanol; at 20 ℃; Alkaline conditions;

With hydrogenchloride; In methanol; water; pH=2;
DOI:10.1021/ml200106d

Reference yield:

: 1333081-08-5
(4-(4-iodophenyl)but-1-yn-1-yl)trimethylsilane

: 1350561-82-8
(E)-3-((3-methyl-5-(4-(4-(thiophen-2-yl)phenethyl)-1H-1,2,3-triazol-1-yl)pent-2-en-1-yl)thio)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / tetrahydrofuran; water / 16 h / 75 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

3.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 20 °C

4.1: methanol / 20 °C / Alkaline conditions

4.2: pH 2

With bis-triphenylphosphine-palladium(II) chloride; copper(ll) sulfate pentahydrate; tetrabutyl ammonium fluoride; sodium carbonate; sodium L-ascorbate; In tetrahydrofuran; methanol; water; tert-butyl alcohol; 1.1: Suzuki coupling;
DOI:10.1021/ml200106d

Reference yield:

: C₁₇H₂₀SSi

: 1350561-82-8
(E)-3-((3-methyl-5-(4-(4-(thiophen-2-yl)phenethyl)-1H-1,2,3-triazol-1-yl)pent-2-en-1-yl)thio)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

2.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 20 °C

3.1: methanol / 20 °C / Alkaline conditions

3.2: pH 2

With copper(ll) sulfate pentahydrate; tetrabutyl ammonium fluoride; sodium L-ascorbate; In tetrahydrofuran; methanol; water; tert-butyl alcohol;
DOI:10.1021/ml200106d