2-Chloro-4-(piperazin-1-yl)pyrimidine

Base Information

Chemical Name:2-Chloro-4-(piperazin-1-yl)pyrimidine
CAS No.:174728-03-1
Molecular Formula:C₈H₁₁ClN₄
Molecular Weight:198.655
Hs Code.:2933990090
DSSTox Substance ID:DTXSID90391878
Wikidata:Q82189643
Mol file:174728-03-1.mol

Synonyms:2-Chloro-4-(piperazin-1-yl)pyrimidine;174728-03-1;2-chloro-4-piperazin-1-ylpyrimidine;2-chloro-4-piperazin-1-yl-pyrimidine;SCHEMBL5585319;DTXSID90391878;AKOS006294682;AB21573;BS-11067;FT-0713959;EN300-1218833;A937548;F1908-2604

Suppliers and Price of 2-Chloro-4-(piperazin-1-yl)pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-CHLORO-4-(PIPERAZIN-1-YL)PYRIMIDINE 95.00%
5MG
$ 495.23

AK Scientific
2-Chloro-4-piperazin-1-yl-pyrimidine
10g
$ 1200.00

AK Scientific
2-Chloro-4-piperazin-1-yl-pyrimidine
5g
$ 850.00

AK Scientific
2-Chloro-4-piperazin-1-yl-pyrimidine
1g
$ 400.00

AK Scientific
2-Chloro-4-piperazin-1-yl-pyrimidine
20mg
$ 89.00

AK Scientific
2-Chloro-4-piperazin-1-yl-pyrimidine
10mg
$ 69.00

Total 3 raw suppliers

Chemical Property of 2-Chloro-4-(piperazin-1-yl)pyrimidine

Chemical Property:

Vapor Pressure:1.35E-06mmHg at 25°C
Refractive Index:1.565
Boiling Point:399.6°Cat760mmHg
Flash Point:195.5°C
PSA：41.05000
Density:1.272g/cm³
LogP:0.93340
XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:198.0672241
Heavy Atom Count:13
Complexity:160

Purity/Quality:

98%min ^*data from raw suppliers

2-CHLORO-4-(PIPERAZIN-1-YL)PYRIMIDINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCN1)C2=NC(=NC=C2)Cl
Uses 2-Chloro-4-piperazin-1-yl-pyrimidine is used as a reactant in the preparation of piperazinylpyrazines and analogs as serotonin 5HT2C receptor modulators for treatment of CNS disorders.

Technology Process of 2-Chloro-4-(piperazin-1-yl)pyrimidine

There total 1 articles about 2-Chloro-4-(piperazin-1-yl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-85-0
piperazine

: 3934-20-1
2,6-Dichloropyrimidine

: 174728-03-1
2-chloro-4-(piperazin-1-yl)pyrimidine

Guidance literature:

Reference yield:

: 174728-03-1
2-chloro-4-(piperazin-1-yl)pyrimidine

: 4-((4-(4-(2-cyanoacetyl)piperazin-1-yl)pyrimidin-2-yl)amino)-N-ethylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 15.33 h / 0 - 15 °C

2: toluene-4-sulfonic acid / 1,4-dioxane / 15 h / 10 - 90 °C

With toluene-4-sulfonic acid; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.8b00917