(2R,3S,4S)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-3-hydroxy-2-<(4-methoxybenzyl)amino>-5-phenylpentanoic acid

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Chemical Name:(2R,3S,4S)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-3-hydroxy-2-<(4-methoxybenzyl)amino>-5-phenylpentanoic acid
CAS No.:164515-11-1
Molecular Formula:C₂₄H₃₂N₂O₆
Molecular Weight:444.528
Hs Code.:

Synonyms:(2R,3S,4S)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-3-hydroxy-2-<(4-methoxybenzyl)amino>-5-phenylpentanoic acid

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Chemical Property of (2R,3S,4S)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-3-hydroxy-2-<(4-methoxybenzyl)amino>-5-phenylpentanoic acid

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Technology Process of (2R,3S,4S)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-3-hydroxy-2-<(4-methoxybenzyl)amino>-5-phenylpentanoic acid

There total 8 articles about (2R,3S,4S)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-3-hydroxy-2-<(4-methoxybenzyl)amino>-5-phenylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 164515-05-3
(2R,3R,4S)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-3-hydroxy-2-<(4-methoxybenzyl)amino>-5-phenylpentanoic acid ethyl ester

: 164515-11-1
(2R,3S,4S)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-3-hydroxy-2-<(4-methoxybenzyl)amino>-5-phenylpentanoic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; for 12h; Ambient temperature;
DOI:10.1021/jm9508696

Reference yield:

: 124818-94-6,116246-06-1
ethyl (2E,4S)-4-[(tert-butoxycarbonyl)amino]-5-phenylpent-2-enoate

: 164515-11-1
(2R,3S,4S)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-3-hydroxy-2-<(4-methoxybenzyl)amino>-5-phenylpentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: MCPBA / CH₂Cl₂ / 20 °C

2: ethanol / 70 °C

3: 1 N LiOH / tetrahydrofuran / 20 °C

With lithium hydroxide; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/S0960-894X(02)00178-6

Reference yield:

: 66605-57-0
(S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol

: 164515-11-1
(2R,3S,4S)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-3-hydroxy-2-<(4-methoxybenzyl)amino>-5-phenylpentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -55 - 20 °C

2: toluene / 80 °C

3: MCPBA / CH₂Cl₂ / 20 °C

4: ethanol / 70 °C

5: 1 N LiOH / tetrahydrofuran / 20 °C

With lithium hydroxide; oxalyl dichloride; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; ethanol; dichloromethane; toluene;
DOI:10.1016/S0960-894X(02)00178-6