2-Thiophenecarboxylicacid,5-ethynyl-(9CI)

Base Information

• Chemical Name: 2-Thiophenecarboxylicacid,5-ethynyl-(9CI)
• CAS No.: 174672-58-3
• Molecular Formula: C7H4 O2 S
• Molecular Weight: 152.174
• Mol file: 174672-58-3.mol

Synonyms:5-(Ethynyl)thiophen-2-carboxylicacid; 5-Ethynylthiophene-2-carboxylic acid

Chemical Property of 2-Thiophenecarboxylicacid,5-ethynyl-(9CI)

Chemical Property:

• PSA: 65.54000
• LogP: 1.42760

Purity/Quality:

99% ^*data from raw suppliers

5-Ethynylthiophene-2-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Thiophenecarboxylicacid,5-ethynyl-(9CI)

There total 6 articles about 2-Thiophenecarboxylicacid,5-ethynyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

5-trimethylsilanylethynylthiophene-2-carboxylic acid methyl ester (177575-35-8) → 5-ethynylthiophene-2-carboxylic acid (174672-58-3)

Guidance literature:

With water; sodium hydroxide; In methanol; at 0 - 20 ℃; for 5h;

DOI:10.1002/anie.201002205

Reference yield: 90.0%

→ 5-ethynylthiophene-2-carboxylic acid (174672-58-3)

Guidance literature:

With sodium hydroxide; In methanol; water; at 20 ℃; for 7h; Cooling with ice;

Reference yield: 80.0%

ethyl 5-(2-trimethylsilyl-ethyn-1-yl)-thiophene-2-carboxylate (881736-66-9) → 5-ethynylthiophene-2-carboxylic acid (174672-58-3)

Guidance literature:

ethyl 5-(2-trimethylsilyl-ethyn-1-yl)-thiophene-2-carboxylate; With sodium hydroxide; water; In ethanol; at 50 ℃; for 4h;

With hydrogenchloride; In water;

upstream raw materials:

ethyl 5-(2-trimethylsilyl-ethyn-1-yl)-thiophene-2-carboxylate

5-trimethylsilanylethynylthiophene-2-carboxylic acid methyl ester

5-bromothiophene-2-carboxylic acid

5-bromo-2-thiophenecarboxylic acid methyl ester

Downstream raw materials:

C₅₂H₄₈Mo₂N₆O₈S

Mo₂(2,4,6-triisopropyl benzoate)2(5-ethynylthiophene-2-carboxylate)2

W₂(2,4,6-triisopropyl benzoate)2(5-ethynylthiophene-2-carboxylate)2

5-ethynylthiophene-2-carboxylic acid 2-aminophenylamide