1H-Pyrrolo[2,3-c]pyridin-5-amine

Base Information

• Chemical Name: 1H-Pyrrolo[2,3-c]pyridin-5-amine
• CAS No.: 174610-12-9
• Molecular Formula: C7H7N3
• Molecular Weight: 133.153
• Hs Code.: 2933990090
• European Community (EC) Number: 887-714-3
• DSSTox Substance ID: DTXSID60597022
• Nikkaji Number: J2.525.302G
• Wikidata: Q82492482
• Mol file: 174610-12-9.mol

Synonyms:1H-Pyrrolo[2,3-c]pyridin-5-amine;174610-12-9;5-AMINO-6-AZAINDOLE;MFCD00817668;5-Amino-1H-pyrrolo[2,3-c]pyridine;SCHEMBL8664673;AMY7228;DTXSID60597022;PFKVAHFIYOMPMX-UHFFFAOYSA-N;ZGA61012;AKOS006273123;CS-W021335;PB12201;DA-21234;DS-12176;SY029479;1H-Pyrrolo[2,3-c]pyridin-5-ylamine TFA salt;EN300-266692;P10150;A881676;J-504772;Z1198155237

Chemical Property of 1H-Pyrrolo[2,3-c]pyridin-5-amine

Chemical Property:

• Boiling Point: 388.5 °C at 760 mmHg
• PKA: 15.05±0.40(Predicted)
• Flash Point: 217.1 °C
• PSA: 54.70000
• Density: 1.367 g/cm³
• LogP: 1.72630
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 133.063997236
• Heavy Atom Count: 10
• Complexity: 126

Purity/Quality:

97% ^*data from raw suppliers

1H-Pyrrolo[2,3-c]pyridin-5-amine 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CNC2=CN=C(C=C21)N
• Uses: 1H-Pyrrolo[2,3-c]pyridin-5-amine is used in the synthesis of pharmaceutical compounds containing pyridine cores.

Technology Process of 1H-Pyrrolo[2,3-c]pyridin-5-amine

There total 4 articles about 1H-Pyrrolo[2,3-c]pyridin-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

N-(1H-pyrrolo[2,3-c]pyridin-5-yl)acetamide (174610-11-8) → 1H-pyrrolo[2,3-c]pyridin-5-amine (174610-12-9)

Guidance literature:

In methanol; methanolic KOH; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;

Reference yield: 22.0%

C9H12N4O2 (960505-80-0) → 1H-pyrrolo[2,3-c]pyridin-5-amine (174610-12-9)

Guidance literature:

With hydrazine hydrate; nickel; In tetrahydrofuran; methanol; at 45 - 50 ℃;

DOI:10.1016/j.tetlet.2007.07.223

Reference yield:

trans-N-(4-(2-(dimethylamino)vinyl)-5-nitropyridin-2-yl)acetamide → 1H-pyrrolo[2,3-c]pyridin-5-amine (174610-12-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / methanol; ethanol; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

2: methanol; methanolic KOH; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

With hydrogen; In methanol; methanolic KOH; ethanol; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;

upstream raw materials:

C₉H₁₂N₄O₂

N-(1H-pyrrolo[2,3-c]pyridin-5-yl)acetamide

N-(4-methyl-5-nitropyridin-2-yl) acetamide