C₆₀H₈₉N₅O₁₂

Base Information

Chemical Name:C₆₀H₈₉N₅O₁₂
CAS No.:186910-20-3
Molecular Formula:C₆₀H₈₉N₅O₁₂
Molecular Weight:1072.39
Hs Code.:

C<sub>60</sub>H<sub>89</sub>N<sub>5</sub>O<sub>12</sub>

Synonyms:C₆₀H₈₉N₅O₁₂

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Chemical Property of C₆₀H₈₉N₅O₁₂

Chemical Property:

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Technology Process of C₆₀H₈₉N₅O₁₂

There total 31 articles about C₆₀H₈₉N₅O₁₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 247107-64-8
(2S,3R,4S,5S,6R,9S,11S)-2-((2S,3S)-7-Bromo-2-hydroxy-3-methyl-hept-6-ynyl)-9-ethyl-4-hydroxy-3,5,11-trimethyl-1-oxa-7-aza-spiro[5.5]undecan-8-one

: 275805-40-8
C₃₈H₅₁IN₄O₈

: 186910-20-3
C₆₀H₈₉N₅O₁₂

Guidance literature:: (2S,3R,4S,5S,6R,9S,11S)-2-((2S,3S)-7-Bromo-2-hydroxy-3-methyl-hept-6-ynyl)-9-ethyl-4-hydroxy-3,5,11-trimethyl-1-oxa-7-aza-spiro[5.5]undecan-8-one; With tri-n-butyl-tin hydride; triphenylphosphine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; at 25 ℃; for 0.5h;

C₃₈H₅₁IN₄O₈; With triphenyl-arsane; N-ethyl-N,N-diisopropylamine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In N,N-dimethyl-formamide; at 40 ℃; for 5h;
DOI:10.1002/(SICI)1521-3773(19990816)38:16<2447::AID-ANIE2447>3.0.CO;2-O

Reference yield:

: 247107-56-8
((2S,3R,4S,5S,6R,9S,11S)-9-Ethyl-4-hydroxy-3,5,11-trimethyl-8-oxo-1-oxa-7-aza-spiro[5.5]undec-2-yl)-acetaldehyde

: 186910-20-3
C₆₀H₈₉N₅O₁₂

Guidance literature:: Multi-step reaction with 14 steps

1.1: 88 percent / 2,6-lutidine / CH₂Cl₂ / -40 - 25 °C

2.1: tetrahydrofuran / -78 °C

2.2: NaBO₃*4H₂O; H₂O / tetrahydrofuran / 12 h / 25 °C

3.1: 88 percent / 2,6-lutidine / CH₂Cl₂ / -40 - 25 °C

4.1: O₃ / CH₂Cl₂ / -78 °C

4.2: 92 percent / PPh₃ / CH₂Cl₂ / 12 h / -78 - 25 °C

5.1: 87 percent / LDA / tetrahydrofuran / 1 h / -78 - -20 °C

6.1: 93 percent / H₂ / Lindlar catalyst / methanol / 12 h / 25 °C

7.1: 94 percent / K₂CO₃ / methanol / 3.5 h / 25 °C

8.1: TBAF

9.1: 2,6-lutidine

10.1: 87 percent / TBAF / tetrahydrofuran / 48 h / 45 °C

11.1: 69 percent / NBS; AgNO₃ / acetone / 0.5 h / 25 °C

12.1: 98 percent / 1 h / 25 °C

13.1: n-Bu₃SnH; Ph₃P / Pd₂(dba)3*CHCl₃ / 0.5 h / 25 °C

13.2: AsPh₃; iPr₂NEt / Pd₂(dba)3*CHCl₃ / dimethylformamide / 10 h / 35 °C

14.1: TBAF / tetrahydrofuran / 2 h / 25 °C

With 2,6-dimethylpyridine; N-Bromosuccinimide; tetrabutyl ammonium fluoride; hydrogen; tri-n-butyl-tin hydride; potassium carbonate; ozone; silver nitrate; triphenylphosphine; lithium diisopropyl amide; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; Lindlar's catalyst; In tetrahydrofuran; methanol; dichloromethane; acetone; 1.1: Etherification / 2.1: Addition / 2.2: Hydrolysis / 3.1: Etherification / 4.1: Oxidation / 4.2: Reduction / 5.1: Condensation / 6.1: Catalytic hydrogenation / 7.1: Substitution / 8.1: Substitution / 9.1: Etherification / 10.1: Substitution / 11.1: Bromination / 12.1: Etherification / 13.1: Metallation / 13.2: Intramolecular Stille reaction / 14.1: Substitution;
DOI:10.1002/(SICI)1521-3773(19990816)38:16<2447::AID-ANIE2447>3.0.CO;2-O

Reference yield:

: 247107-57-9
((2S,3S,4S,5S,6R,9S,11S)-9-Ethyl-3,5,11-trimethyl-8-oxo-4-triethylsilanyloxy-1-oxa-7-aza-spiro[5.5]undec-2-yl)-acetaldehyde

: 186910-20-3
C₆₀H₈₉N₅O₁₂

Guidance literature:: Multi-step reaction with 13 steps

1.1: tetrahydrofuran / -78 °C

1.2: NaBO₃*4H₂O; H₂O / tetrahydrofuran / 12 h / 25 °C

2.1: 88 percent / 2,6-lutidine / CH₂Cl₂ / -40 - 25 °C

3.1: O₃ / CH₂Cl₂ / -78 °C

3.2: 92 percent / PPh₃ / CH₂Cl₂ / 12 h / -78 - 25 °C

4.1: 87 percent / LDA / tetrahydrofuran / 1 h / -78 - -20 °C

5.1: 93 percent / H₂ / Lindlar catalyst / methanol / 12 h / 25 °C

6.1: 94 percent / K₂CO₃ / methanol / 3.5 h / 25 °C

7.1: TBAF

8.1: 2,6-lutidine

9.1: 87 percent / TBAF / tetrahydrofuran / 48 h / 45 °C

10.1: 69 percent / NBS; AgNO₃ / acetone / 0.5 h / 25 °C

11.1: 98 percent / 1 h / 25 °C

12.1: n-Bu₃SnH; Ph₃P / Pd₂(dba)3*CHCl₃ / 0.5 h / 25 °C

12.2: AsPh₃; iPr₂NEt / Pd₂(dba)3*CHCl₃ / dimethylformamide / 10 h / 35 °C

13.1: TBAF / tetrahydrofuran / 2 h / 25 °C

With 2,6-dimethylpyridine; N-Bromosuccinimide; tetrabutyl ammonium fluoride; hydrogen; tri-n-butyl-tin hydride; potassium carbonate; ozone; silver nitrate; triphenylphosphine; lithium diisopropyl amide; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; Lindlar's catalyst; In tetrahydrofuran; methanol; dichloromethane; acetone; 1.1: Addition / 1.2: Hydrolysis / 2.1: Etherification / 3.1: Oxidation / 3.2: Reduction / 4.1: Condensation / 5.1: Catalytic hydrogenation / 6.1: Substitution / 7.1: Substitution / 8.1: Etherification / 9.1: Substitution / 10.1: Bromination / 11.1: Etherification / 12.1: Metallation / 12.2: Intramolecular Stille reaction / 13.1: Substitution;
DOI:10.1002/(SICI)1521-3773(19990816)38:16<2447::AID-ANIE2447>3.0.CO;2-O