(2S,4S)-1-ethyl 2-methyl 4-(4-nitrobenzoyloxy)pyrrolidine-1,2-dicarboxylate

Base Information

Chemical Name:(2S,4S)-1-ethyl 2-methyl 4-(4-nitrobenzoyloxy)pyrrolidine-1,2-dicarboxylate
CAS No.:1103893-36-2
Molecular Formula:C₁₆H₁₈N₂O₈
Molecular Weight:366.328
Hs Code.:

Synonyms:(2S,4S)-1-ethyl 2-methyl 4-(4-nitrobenzoyloxy)pyrrolidine-1,2-dicarboxylate

Suppliers and Price of (2S,4S)-1-ethyl 2-methyl 4-(4-nitrobenzoyloxy)pyrrolidine-1,2-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (2S,4S)-1-ethyl 2-methyl 4-(4-nitrobenzoyloxy)pyrrolidine-1,2-dicarboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2S,4S)-1-ethyl 2-methyl 4-(4-nitrobenzoyloxy)pyrrolidine-1,2-dicarboxylate

There total 1 articles about (2S,4S)-1-ethyl 2-methyl 4-(4-nitrobenzoyloxy)pyrrolidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 172947-80-7
(2S,4R)-1-ethyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate

: 62-23-7
4-nitro-benzoic acid

: 1103893-36-2
(2S,4S)-1-ethyl 2-methyl 4-(4-nitrobenzoyloxy)pyrrolidine-1,2-dicarboxylate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 ℃;
DOI:10.1002/chem.200801582

Reference yield:

: 1103893-36-2
(2S,4S)-1-ethyl 2-methyl 4-(4-nitrobenzoyloxy)pyrrolidine-1,2-dicarboxylate

: 1103893-52-2
((2S,4S)-2(hydroxydiphenylmethyl)-4-methoxypyrrolidin-1-yl)(pyridin-2-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / methanol / 6 h / 20 °C

2: tetrahydrofuran / 9 h / 0 - 20 °C

3: sodium hydride / tetrahydrofuran / 6 h / 0 °C / Cooling

4: water / methanol / 24 h / Reflux

5: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 0 - 20 °C

With 4-methyl-morpholine; water; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/chem.200801582

Reference yield:

: 1103893-36-2
(2S,4S)-1-ethyl 2-methyl 4-(4-nitrobenzoyloxy)pyrrolidine-1,2-dicarboxylate

: (2S,4S)-ethyl 4-hydroxy-2-(hydroxydiphenylmethyl)pirrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / methanol / 6 h / 20 °C

2: tetrahydrofuran / 9 h / 0 - 20 °C

With potassium carbonate; In tetrahydrofuran; methanol;
DOI:10.1002/chem.200801582