TRANS-1-ETHOXY-2,3-DIFLUORO-4-(4-PROPYL-CYCLOHEXYL)-BENZENE

Base Information

• Chemical Name: TRANS-1-ETHOXY-2,3-DIFLUORO-4-(4-PROPYL-CYCLOHEXYL)-BENZENE
• CAS No.: 174350-05-1
• Molecular Formula: C₁₇H₂₄F₂O
• Molecular Weight: 282.374
• Hs Code.: 2909309090
• Mol file: 174350-05-1.mol

Synonyms:Benzene,1-ethoxy-2,3-difluoro-4-(4-propylcyclohexyl)-, trans-; PCH 302FF

Chemical Property of TRANS-1-ETHOXY-2,3-DIFLUORO-4-(4-PROPYL-CYCLOHEXYL)-BENZENE

Chemical Property:

• Vapor Pressure: 0-0.062Pa at 20-50℃
• Refractive Index: 1.477
• Boiling Point: 325.6±42.0 °C(Predicted)
• PSA: 9.23000
• Density: 1.031±0.06 g/cm3(Predicted)
• LogP: 5.43740
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99.9% ^*data from raw suppliers

1-Ethoxy-2,3-difluoro-4-((1s,4r)-4-propylcyclohexyl)benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Ethoxy-2,3-difluoro-4-((1s,4r)-4-propylcyclohexyl)benzene is a part of a polymerizable composition that is used in LCD (liquid crystal display).

Technology Process of TRANS-1-ETHOXY-2,3-DIFLUORO-4-(4-PROPYL-CYCLOHEXYL)-BENZENE

There total 8 articles about TRANS-1-ETHOXY-2,3-DIFLUORO-4-(4-PROPYL-CYCLOHEXYL)-BENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-ethoxy-2,3-difluoro-4-(4-propylenecyclohexyl)benzene → 1-ethoxy-2,3-difluoro-4-(trans-4-propylcyclohexyl)benzene (174350-08-4,174350-05-1)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In ethanol; at 50 ℃; under 2250.23 - 3750.38 Torr;

Reference yield:

C17H22F2O → 2,3-difluoro-1-(4-propylcyclohexyl)-4-ethoxybenzene (174350-05-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 60 ℃; for 10h;

Reference yield:

1-ethoxy-2,3-difluorobenzene → 1-ethoxy-2,3-difluoro-4-(trans-4-propylcyclohexyl)benzene (174350-08-4,174350-05-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: n-butyllithium / ethanol / 1 h / -78 - -70 °C

1.2: 1 h / -60 °C

2.1: toluene-4-sulfonic acid / ethylene glycol / 5 h / Reflux

3.1: 5%-palladium/activated carbon; hydrogen / ethanol / 40 °C / 2250.23 - 3750.38 Torr

3.2: 4 h / Reflux

4.1: potassium tert-butylate / tetrahydrofuran / 0.33 h / -10 - 0 °C

4.2: 2 h / -5 °C

5.1: 5%-palladium/activated carbon; hydrogen / ethanol / 50 °C / 2250.23 - 3750.38 Torr

With n-butyllithium; 5%-palladium/activated carbon; potassium tert-butylate; hydrogen; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; ethylene glycol; 4.1: |Wittig Olefination / 4.2: |Wittig Olefination;

upstream raw materials:

8-(4-ethoxy-2,3-difluorophenyl)-1,4-dioxaspiro[4.5]decane-8-ol

8-(4-ethoxy-2,3-difluorophenyl)-1,4-dioxaspiro[4.5]dec-7-ene

4-(2,3-difluoro-4-ethoxyphenyl)-cyclohexanone

cyclohexanedione monoethylene ketal

Refernces

• 1、 -. "Method of producing hydrogen of the reaction product and substrate". Paragraph 0055; 0056. . Retrieved 2017/03/24.