Boc-D-Ala-Phe-Gly-OH

Base Information

• Chemical Name: Boc-D-Ala-Phe-Gly-OH
• CAS No.: 100304-64-1
• Molecular Formula: C₁₉H₂₇N₃O₆
• Molecular Weight: 393.44
• Mol file: 100304-64-1.mol

Synonyms:Boc-D-Ala-Phe-Gly-OH

Chemical Property of Boc-D-Ala-Phe-Gly-OH

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-D-Ala-Phe-Gly-OH

There total 2 articles about Boc-D-Ala-Phe-Gly-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

Boc-D-Ala-Phe-Gly-OBzl (82487-57-8) → Boc-D-Ala-Phe-Gly-OH (100304-64-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; for 3h; Ambient temperature;

Reference yield: 78.0%

N-Boc-D-alanyl-L-phenylalanyl-glycine ethyl ester (78330-90-2) → Boc-D-Ala-Phe-Gly-OH (100304-64-1)

Guidance literature:

With sodium hydroxide; In methanol; for 0.833333h; Ambient temperature;

DOI:10.1248/cpb.33.4865

Reference yield:

Boc-D-Ala-Phe-Gly-OH (100304-64-1) → H-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2 (100304-58-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / WSCI, HOBt / dimethylformamide; triethylamine / 40 h / 5 °C

2: 54 percent / 4N HCl-DOX / H₂O / 1 h / Ambient temperature

With hydrogenchloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In water; triethylamine; N,N-dimethyl-formamide;

DOI:10.1248/cpb.33.4865

upstream raw materials:

Boc-D-Ala-Phe-Gly-OBzl

N-Boc-D-alanyl-L-phenylalanyl-glycine ethyl ester

Downstream raw materials:

Boc-D-Ala-Phe-Gly-Phe-NH₂

Boc-D-Ala-Phe-Gly-NH₂

H-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH₂

(allyl)2Tyr(t-Bu)-D-Ala-Phe-Gly-Phe-NH₂

Refernces

• 1、 Suzuki,Fujita,Matsui,Sasaki,Sakurada,Sakurada,Kisara. "Studies on analgesic oligopeptides. IV. Synthesis and analgesic activity of N-terminal shorter analogs of [D-Arg2]dermorphin and Des-Tyr1-dermorphin analogs". . p. 4865 - 4869. Retrieved 2007/10/02.