(S)-4-(3-(2-cyanophenoxy)-2-hydroxypropylamino)-N-(6-fluoropyridin-3-yl)butanamide

Base Information

Chemical Name:(S)-4-(3-(2-cyanophenoxy)-2-hydroxypropylamino)-N-(6-fluoropyridin-3-yl)butanamide
CAS No.:1323276-52-3
Molecular Formula:C₁₉H₂₁FN₄O₃
Molecular Weight:372.399
Hs Code.:

Synonyms:(S)-4-(3-(2-cyanophenoxy)-2-hydroxypropylamino)-N-(6-fluoropyridin-3-yl)butanamide

Suppliers and Price of (S)-4-(3-(2-cyanophenoxy)-2-hydroxypropylamino)-N-(6-fluoropyridin-3-yl)butanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-4-(3-(2-cyanophenoxy)-2-hydroxypropylamino)-N-(6-fluoropyridin-3-yl)butanamide

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Technology Process of (S)-4-(3-(2-cyanophenoxy)-2-hydroxypropylamino)-N-(6-fluoropyridin-3-yl)butanamide

There total 3 articles about (S)-4-(3-(2-cyanophenoxy)-2-hydroxypropylamino)-N-(6-fluoropyridin-3-yl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1355672-48-8
C₉H₁₂FN₃O

: 93744-18-4
(S)-(+)-3-(2-cyanophenoxy)-1,2-epoxypropane

: 1323276-52-3
(S)-4-(3-(2-cyanophenoxy)-2-hydroxypropylamino)-N-(6-fluoropyridin-3-yl)butanamide

Guidance literature:: With diethyl methoxy borane; N-ethyl-N,N-diisopropylamine; ytterbium(III) triflate; In acetonitrile; at 74 - 85 ℃;
DOI:10.1021/ml1002458

Reference yield:

: 1323277-18-4
tert-butyl 4-(6-fluoropyridin-3-ylamino)-4-oxobutylcarbamate

: 1323276-52-3
(S)-4-(3-(2-cyanophenoxy)-2-hydroxypropylamino)-N-(6-fluoropyridin-3-yl)butanamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 20 °C

2: diethyl methoxy borane; N-ethyl-N,N-diisopropylamine; ytterbium(III) triflate / acetonitrile / 74 - 85 °C

With diethyl methoxy borane; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; ytterbium(III) triflate; In dichloromethane; acetonitrile;
DOI:10.1021/ml1002458

Reference yield:

: 1827-27-6
2-fluoro-5-aminopyridine

: 1323276-52-3
(S)-4-(3-(2-cyanophenoxy)-2-hydroxypropylamino)-N-(6-fluoropyridin-3-yl)butanamide

Guidance literature:: Multi-step reaction with 3 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 20 °C

3: diethyl methoxy borane; N-ethyl-N,N-diisopropylamine; ytterbium(III) triflate / acetonitrile / 74 - 85 °C

With diethyl methoxy borane; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; ytterbium(III) triflate; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ml1002458